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The nuclear pore complex is one of the largest structural organelles within the eukaryotic cell. About 30 individual nucleoporins constitute the yeast NPC. About half of these nucleoporins were identified in my laboratory by genetic and biochemical methods. Several nucleoporins were isolated in stable association with each other and thus represent sucomplexes of the nuclear pore complex. The Nup84p complex composed of six subunits has functions both in pore biogenesis and in mRNA transport processes. By a genetic screen using a mutant of the Nup84p complex, we have found the Mex67p/Mtr2p complex and its mammalian TAP/p15 counterpart, and shown that these complexes act as a shuttling receptor for nuclear mRNA export.
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NUCLEIC ACIDS RESEARCHno. 4 (2024): 1975-1987
Cellno. 5 (2024): 1314-1314.e1
Sven Reislöhner,Geza Schermann,Max Kilian, Daniela Santamaría-Muñoz, Christian Zimmerli,Nikola Kellner,Jochen Baßler,Michael Brunner,Ed Hurt
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Nestor Miguel Castillo Duque de Estrada,Matthias Thoms,Dirk Flemming,Henrik M. Hammaren,Robert Buschauer,Michael Ameismeier,Jochen Baßler,Martin Beck,Roland Beckmann,Ed Hurt
Nature Structural & Molecular Biologyno. 8 (2023): 1119-1131
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Scientific reportsno. 1 (2023): 1938-1938
The Journal of cell biologyno. 6 (2023)
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Matthias Thoms,Benjamin Lau,Jingdong Cheng, Lisa Fromm,Timo Denk,Nikola Kellner,Dirk Flemming, Paulina Fischer,Laurent Falquet,Otto Berninghausen,Roland Beckmann,Ed Hurt
EMBO reports (2023)
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