基本信息
浏览量:93
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Receptor tyrosine kinases of the Eph family and their ligands, the ephrins, represent an important cell communication system that controls a vast array physiological and disease processes. For example, Eph receptors and ephrins take part in the formation of blood vessels, including the blood vessels that feed tumors, and regulate the malignant properties of cancer cells and their interplay with the tumor microenvironment. They also regulate the formation, plasticity and regeneration of neuronal circuits as well as neurodegenerative processes such as those occurring in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. The signal transduction mechanisms of Eph receptors are intriguing, and complex, because these receptors engage in multiple modes of signaling. Binding to ephrin ligands on the surface of neighboring cells induces canonical signaling involving receptor clustering, autophosphorylation on tyrosine residues, and kinase activity-dependent downstream signaling. Binding to the Eph receptors can also cause the ephrins, which have a cytoplasmic domain or a GPI-anchor, to transmit signals. This leads to bidirectional signals emanating from Eph receptor-ephrin complexes positioned at sites of cell-cell contact. In addition, at least some Eph receptors can also signal through non-canonical mechanisms that are independent of ligand binding and kinase activity, for example through interplay with other receptor tyrosine kinase families and with serine/threonine kinases.
Our research investigates Eph receptor signaling activities in order to understand their role in normal physiology and in pathological conditions such as cancer and neurodegenerative disorders. This knowledge is useful for the development of disease treatments based on modulating Eph receptor/ephrin activities. Ongoing efforts in our laboratory also focus on the development of agents targeting Eph receptors for research and translational applications.
Our research investigates Eph receptor signaling activities in order to understand their role in normal physiology and in pathological conditions such as cancer and neurodegenerative disorders. This knowledge is useful for the development of disease treatments based on modulating Eph receptor/ephrin activities. Ongoing efforts in our laboratory also focus on the development of agents targeting Eph receptors for research and translational applications.
研究兴趣
论文共 270 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Joshua P. Sasine, Natalia Y. Kozlova, Lisa Valicente, Jennifer Dukov, Dana H. Tran,Heather A. Himburg, Sanjeev Kumar, Sarah Khorsandi, Aldi Chan, Samantha Grohe,Michelle Li,Jenny Kan,
crossref(2024)
Journal of Biological Chemistrypp.107441-107441, (2024)
Joshua P. Sasine, Natalia Y. Kozlova, Lisa Valicente, Jennifer Dukov, Dana H. Tran,Heather A. Himburg, Sanjeev Kumar, Sarah Khorsandi, Aldi Chan, Samantha Grohe,Michelle Li,Jenny Kan,
CANCER RESEARCHno. 6 (2024): 919-934
Shilpa Bhatia,Ayman Oweida, Shelby Lennon,Laurel B. Darragh, Dallin Milner,Andy V. Phan,Adam C. Mueller,Benjamin Van Court,David Raben,Natalie J. Serkova,Xiao-Jing Wang,Antonio Jimeno,
crossref(2023)
Nature reviews. Cancerno. 1 (2023): 5-27
Shilpa Bhatia,Ayman Oweida, Shelby Lennon,Laurel B. Darragh, Dallin Milner,Andy V. Phan,Adam C. Mueller,Benjamin Van Court,David Raben,Natalie J. Serkova,Xiao-Jing Wang,Antonio Jimeno,
crossref(2023)
Shilpa Bhatia,Ayman Oweida, Shelby Lennon,Laurel B. Darragh, Dallin Milner,Andy V. Phan,Adam C. Mueller,Benjamin Van Court,David Raben,Natalie J. Serkova,Xiao-Jing Wang,Antonio Jimeno,
crossref(2023)
crossref(2023)
Shilpa Bhatia,Ayman Oweida, Shelby Lennon,Laurel B. Darragh, Dallin Milner,Andy V. Phan,Adam C. Mueller,Benjamin Van Court,David Raben,Natalie J. Serkova,Xiao-Jing Wang,Antonio Jimeno,
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn