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Dr Morris and his students have been working on kinetic models to estimate the dynamics of endogenous neurotransmitters from PET data. Their most recent publication appeared in Neuroimage in 2010. It demonstrates a novel analysis strategy for creating the first ever “movies” of dopamine action in the living brain. Altered neurotransmitter kinetics may explain the mechanism of addiction of some drugs. This work uses knowledge of numerical methods, biochemistry, image and signal processing, parameter estimation, and programming. A collection of papers to result from this project can be downloaded as a zip file here. The work was funded by the Whitaker Foundation and the National Institute on Alcohol Abuse and Alcoholism.
Morris and his colleagues at Indiana University have focused much of their efforts on the use of PET to understand what makes drugs and alcohol addictive. It is the first demonstration in humans of the neurochemistry of reward prediction error. This work uses knowledge of neuropsychology, image processing, experimental study design, neurochemistry, and kinetic modeling.
Morris is currently interested in the use of PET imaging (of people and animals) with neuroreceptor tracers to understand and improve treatments for Parkinson’s disease, alcoholism, smoking, and drug abuse.
Morris and his colleagues at Indiana University have focused much of their efforts on the use of PET to understand what makes drugs and alcohol addictive. It is the first demonstration in humans of the neurochemistry of reward prediction error. This work uses knowledge of neuropsychology, image processing, experimental study design, neurochemistry, and kinetic modeling.
Morris is currently interested in the use of PET imaging (of people and animals) with neuroreceptor tracers to understand and improve treatments for Parkinson’s disease, alcoholism, smoking, and drug abuse.
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论文共 149 篇作者统计合作学者相似作者
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Bart de Laat,Jocelyn Hoye,Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan,Dustin W. Wooten,Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna,Yiyun Huang,
NPJ PARKINSONS DISEASEno. 1 (2024)
Bart de Laat,Jocelyn Hoye,Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan,Dustin W. Wooten,Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna,Yiyun Huang,
npj Parkinson's Diseaseno. 1 (2024): 1-7
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Y. Zakiniaeiz,H. Liu,H. Gao, S. Najafzadeh, J. Ropchan,N. Nabulsi,Y. Huang,D. Matuskey,M. Chen,K. Cosgrove,E. Morris
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S. Tinaz, B. De laat, G. Stanley,J. Hoye, J. Key, M. Hespeler, J. Ligi,Y. Huang,N. Nabulsi,E. Morris
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