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Dr. E. John Wherry is currently the Chair, Department of Systems Pharmacology and Translational Therapeutics, Richard and Barbara Schiffrin President’s Distinguished Professor and Director, Institute for Immunology at the Perelman School of Medicine at the University of Pennsylvania. Dr. Wherry’s expertise focuses on T cell exhaustion in chronic infections and cancer and on the mechanisms by which immunoregulatory “checkpoint” pathways such as PD-1 control T cell exhaustion. Dr. Wherry’s work has defined the molecular mechanisms of T cell exhaustion, including defining the role of inhibitory receptor biology, transcriptional control and regulation of T cell differentiation. This work has helped define key principles about inhibitory receptor blockade and co-blockade to reverse T cell exhaustion (e.g. coblockade of PD-1 and LAG3, etc).
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论文共 54 篇作者统计合作学者相似作者
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Jennifer L. Hope, Christopher J. Stairiker,Panagiota I. Spantidea,Donald T. Gracias,Alison J. Carey,Adam J. Fike,Marjan van Meurs,Inge Brouwers-Haspels,Laurine C. Rijsbergen,Joseph A. Fraietta,Yvonne Mueller, Rosemarieke C. Klop,
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Alexander C. Huang,Michael A. Postow,Robert J. Orlowski,Rosemarie Mick,Bertram Bengsch,Sasi Manne,Wei Xu,Shannon Harmon,Matthew Adamow,Deborah Kuk, Katherine Panangeas, Cristina Carerra,
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