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个人简介
My research focuses on studying factors involved in the health / disease balance, which regulate the immune system in conditions of infection/ autoimmunity. I performed my Doctoral Thesis at Institute of Parasitology and Biomedicine (Spanish National Research Council-CSIC), Granada-1997-2003, with stays at Uppsala University, Sweden-1998; Yale School of Medicine, USA-1999 and Seattle Biomedical Research Institute, USA-2000). In 2003, I started my postdoctoral [Dr. Delgado (IPBLN, CSIC) and Dr. Ganea (RutgersUniv.New Jersey, USA)], focusing on the role of endogenous neuropeptides (1), and maintenance of immunological tolerance, demonstrating their therapeutic effects in preclinical models of autoimmunity. In 2006, I established myself as an independent researcher with a Postdoctoral contract (FIS) at the Faculty of Medicine (Univ. Sevilla), collaborating with Dr. Pozo (CABIMER, Sevilla) and Dr. Ganea (Temple Univ., Philadelphia, USA) . In this period I studied the molecular mechanisms of these neuropeptides in the generation of regulatory T cells and tolerogenic cells. Also, studying immunoregulation and in collaboration with the company TiGenix, we describe for the first time the immunoregulatory effect of mesenchymal cells derived from adipose tissue (2). In 2010, I consolidated my research group with the Ramón y Cajal contract, and I settled in the IPBLN-CSIC. Since then I have worked on two new lines of research. On the one hand, I discovered a new role for neuropeptides in the innate response as antimicrobial and antiparasitic agents (3). Related to this line of research, I was part of the management committee of the ACTION COST EUROPEAN BM0802 until 2013. Also during this period I was interested in deepening the immunoregulatory effect of these neuropeptides in disorders of the central nervous system (4), considered as degenerative pathologies (multiple sclerosis, Alzheimer's disease, Parkinson's), in which the neuroinflammation associated with an uncontrolled immune response. In this context we are studying the therapeutic and physiological effect of cortistatin, with promising results that have been published in high impact journals in the area such as Glia, BBI, J. Immunol, etc. In general, I have participated in 29 projects (IP: 7, Co-IP: 6). These results have aroused the interest of pharmaceutical companies such as Palau Pharma (Barcelona), Tigenix (Belgium), BCN Peptides and ORYZON Genomics, with which I have coordinated different projects. My research activity has resulted in the licensing of 5 international patents for the treatment of inflammatory and neurodegenerative diseases. Publications related to the subject show my experience in different crucial fields: chronic inflammation, immunomodulation, neurodegeneration, neuroinflammation, and management of animal models. Currently I have a permanent position as Group Leader (Principal Research Scientist) with which I intend to develop my line of research based on the study of cortistatin as a molecular link in the Immunological interaction between periphery and the glial niche in CNS disorders.
研究兴趣
论文共 159 篇作者统计合作学者相似作者
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J Castillo-González,L Buscemi, P Vargas-Rodríguez,I Serrano-Martínez,I Forte-Lago, M Price,P Hernández-Cortés,L Hirt,E González-Rey
biorxiv(2024)
Julia Castillo-González, José Luis Ruiz,Ignacio Serrano-Martínez,Irene Forte-Lago,Ana Ubago-Rodriguez,Marta Caro,Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso,Eduardo Andrés-León,Macarena Sánchez-Navarro,Raúl M. Luque,Elena González-Rey
Journal of Neuroinflammationno. 1 (2023): 1-25
Pablo Vargas-Rodriguez, Alejandro Cuenca-Martagon,Julia Castillo-Gonzalez,Ignacio Serrano-Martinez,Raul M. Luque,Mario Delgado,Elena Gonzalez-Rey
José L Ruiz,Laura C Terrón-Camero,Julia Castillo-González, Iván Fernández-Rengel,Mario Delgado,Elena Gonzalez-Rey,Eduardo Andrés-León
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Ana Isabel Sánchez-Castillo,M Rosario Sepúlveda,José Luis Marín-Teva,Miguel A Cuadros,David Martín-Oliva,Elena González-Rey,Mario Delgado,Veronika E Neubrand
Clara P Falo,Raquel Benitez,Marta Caro,Maria Morell,Irene Forte-Lago,Pedro Hernandez-Cortes, Clara Sanchez-Gonzalez,Francisco O'Valle,Mario Delgado,Elena Gonzalez-Rey
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