Eleanor G Rogan
教授
Department of Health Promotion
College of Public Health, University of Nebraska Medical Center;Department of Environmental, Agricultural & Occupational Health, College of Public Health, University of Nebraska Medical Center;Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
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基本信息
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个人简介
My research centers around elucidating mechanisms of activation of carcinogens, identifying carcinogen-DNA adducts, and correlating adducts with oncogenic mutations. From our previous study of polycyclic aromatic hydrocarbon (PAH) metabolism and DNA adducts, we have demonstrated that the predominant adducts are lost by depurination, leaving mutagenic apurinic sites in the DNA. This research involved identification and quantitation of PAH-DNA adducts and correlation of the adducts with Harvey-ras mutations in mouse skin papillomas induced by the PAH. We have extended our studies to endogenous catechol estrogen metabolites and found that the carcinogenic metabolites form depurinating N3Ade and N7Gua adducts in DNA. We hypothesize that this is the pathway of initiation for human breast, ovarian, thyroid, prostate and other cancers. Studies in test tubes, laboratory animal models, cell culture models and human subjects have demonstrated the validity of this hypothesis. Now we are working on the early detection of cancer risk and prevention of cancer by selected natural compounds.
研究兴趣
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Varun Kumar,Neha Deshpande,Mohit Parekh,Raymond Wong,Shazia Ashraf,Muhammad Zahid, Hanna Hui,Annie Miall, Sylvie Kimpton,Marianne O. Price,Francis W. Price Jr,Frank J. Gonzalez,
REDOX BIOLOGY (2024): 102986-102986
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobaccono. Suppl_1 (2023): S84-S93
International journal of environmental research and public healthno. 21 (2023): 6967-6967
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