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As a plant molecular geneticist I have studied the mechanisms controlling floral development. Through extensive mutant screens in Antirrhinum (snapdragon) I identified and characterized three classes of key regulatory genes, most of which encode transcription factors. The first class comprises genes that control the switch from shoot to floral meristems and therefore sets the overall architecture of the plant. The second class consists of genes that act in combination to establish the basic plan of the flower as a series of concentric whorls of different organ types. This work, together with parallel studies in Arabidopsis, led to a unified model of flower development, termed the ABC model, which has provided a framework for subsequent studies in the field. The third class of genes controls the dorsoventral asymmetry of the flower. This has allowed the development and evolution of floral asymmetry to be studied at the molecular level for the first time. More recently I have been trying to understand how patterns of gene activity lead to the growth of organs with specific sizes and shapes. This involves a combination of experimental studies and mathematical modeling.
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论文共 128 篇作者统计合作学者相似作者
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Jie Cheng,Xu Yao, Xukun Li,Liang Yue,Xiaoshan Duan, Boka Li,Xuehao Fu,Shuixian Li,Hongyan Shan,Xiaofeng Yin,Christopher Whitewoods,Enrico Coen,
Robert Kelly-Bellow,Karen Lee,Richard Kennaway,Elaine Barclay,Annabel Whibley, Claire Bushell,Jamie Spooner,Man Yu, Paul Brett,Baldeep Kular,Shujing Cheng,Jinfang Chu,
biorxiv(2023)
James W. Satterlee, Lukas J. Evans,Brianne R. Conlon, Phillip Conklin,Jesus Martinez-Gomez, Jeffery R. Yen, Hao Wu,Anne W. Sylvester,Chelsea D. Specht,Jie Cheng,Robyn Johnston,Enrico Coen,
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MOLECULAR BIOLOGY AND EVOLUTIONno. 4 (2023)
Hong Zhao,Yue Zhang,Hui Zhang,Yanzhai Song,Fei Zhao,Yu'e Zhang,Sihui Zhu, Hongkui Zhang, Zhendiao Zhou,Han Guo,Miaomiao Li,Junhui Li,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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