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Dr. Chang's laboratory studies intestinal microbes and viruses (the microbiome), particularly as they relate to health, digestive diseases (IBD) and other immune- and metabolic-related disorders. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. The emergence of “Western” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. His efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease.
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Moleculesno. 6 (2024): 1401
Molecules (Basel, Switzerland)no. 6 (2024)
Megan E. Bosch,Hemraj B. Dodiya,Julia Michalkiewicz,Choonghee Lee,Shabana M. Shaik,Ian Q. Weigle,Can Zhang, Jack Osborn, Aishwarya Nambiar,Priyam Patel,Samira Parhizkar,Xiaoqiong Zhang,
Molecular Neurodegenerationno. 1 (2024): 1-26
MBIOno. 1 (2024): e0283023-e0283023
JOURNAL OF BACTERIOLOGYno. 1 (2024): e0042623-e0042623
Eugene B Chang,Margaret S Bohm,Laura M Sipe, Sydney C Joseph, Boston W Simmons, Madeline E Pye,Ashley M Sidebottom,Joseph F Pierre,Liza Makowski
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Gastroenterologyno. 6 (2023): S-194-S194
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American Journal of Physiology-cell Physiologyno. 1 (2023): C344-C361
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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