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Despite possessing a resident pool of neural stem cells, the mammalian brain and spinal cord shows a limited ability to regenerate damaged tissue after traumatic injury. Instead, injury initiates a cascade of events that direct reactive gliosis to wall off an injury with a glial scar to mitigate damage and preserve function. My current research interests explore approaches to re-engineer the stem cell niche, to utilize gene-therapy and genome editing approaches to reprogram and engineer stem cells directly, and to enhance drug delivery into the central nervous system (CNS) to drive regenerative strategies that augment functional recovery in the diseased or traumatically injured CNS.
Despite possessing a resident pool of neural stem cells, the mammalian brain and spinal cord shows a limited ability to regenerate damaged tissue after traumatic injury. Instead, injury initiates a cascade of events that direct reactive gliosis to wall off an injury with a glial scar to mitigate damage and preserve function. My current research interests explore approaches to re-engineer the stem cell niche, to utilize gene-therapy and genome editing approaches to reprogram and engineer stem cells directly, and to enhance drug delivery into the central nervous system (CNS) to drive regenerative strategies that augment functional recovery in the diseased or traumatically injured CNS.
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论文共 44 篇作者统计合作学者相似作者
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Dinh Chuong Nguyen,Kefan Song, Simbarashe Jokonya, Omeed Yazdani,Drew L. Sellers, Yonghui Wang, A. B. M. Zakaria,Suzie H. Pun,Patrick S. Stayton
ACS CENTRAL SCIENCEno. 3 (2024): 666-675
Dinh Chuong Nguyen,Kefan Song, Simbarashe Jokonya, Omeed Yazdani,Drew L. Sellers, Yonghui Wang, A. B. M. Zakaria, Suzie H. Pun,Patrick S. Stayton
ACS CENTRAL SCIENCE (2024)
Dinh Chuong Nguyen,Kefan Song, Simbarashe Jokonya, Omeed Yazdani,Drew L. Sellers, Yonghui Wang, ABM Zakaria,Suzie H. Pun,Patrick S. Stayton
ACS Central Science (2024)
Hunter R. Underhill,Michael Karsy,Christian J. Davidson, Sabine Hellwig, Samuel Stevenson,Eric A. Goold, Sydney Vincenti,Drew L. Sellers, Charlie Dean, Brion E. Harrison,Mary P. Bronner,Howard Colman,
CANCER RESEARCHno. 7 (2024): 1149-1164
The Journal of biological chemistry (2021): 100657-100657
bioRxiv (Cold Spring Harbor Laboratory) (2020)
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