Scientific Directions: 1) Understand the regulation of α-synuclein (SNCA) expression - the most critical gene for Parkinson's disease (PD) pathogenesis. 2) Manipulate SNCA levels for therapy. 3) Pinpoint PD/PD+ biomarkers. 4) Explore specific and global aspects of post-transcriptional gene regulation mediated by neuronally-enriched RNA-binding proteins (RBPs), miRNAs, and circRNAs in PD.