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Rheumatoid arthritis is an autoimmune disorder that effects 1.3 million people nationwide and has no known cure. The onset and progression of rheumatoid arthritis involves the complex interplay of a variety of cell types including macrophages, osteoclasts, and dendritic cells. Many of these cell are derived from or can be derived from monocytic precursors. The focus of our research is to better understand the molecular mechanisms that drive the transition from monocytes to each of these disease-relevant cell types. We are particularly interested in the phenomena of dynamic DNA looping and kinase signaling and the role that they play in lineage specificity and cell fate decisions. By better understanding the mechanisms that give rise to these cells we can improve our understanding of rheumatoid arthritis and potentially identify novel therapeutic targets. However, the knowledge we gain regarding gene regulation and cell signaling with inform our understanding of a wide variety of biological processes and human diseases. We employ a variety of technologies including genomics, proteomics, genome editing, and bioinformatics to characterize and functionally test molecular events driving monocyte differentiation.
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论文共 62 篇作者统计合作学者相似作者
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Nicole Kramer, Seyoun Byun,Philip Coryell,Eliza Thulson, Susan D'Costa, HyunAh Kim, Susan Chubinskaya,Karen Mohlke,Brian Diekman,Richard F. Loeser,Douglas Phanstiel
Osteoarthritis and Cartilage (2024): S487-S488
Richard F. Loeser,Philip Coryell,Kenneth Pearce, Nicole Kramer, Grace Kenney, Jingyui Lee, Susan Chubinskaya,Cristina Furdui,Douglas Phanstiel
Osteoarthritis and Cartilage (2024): S468-S469
bioRxiv : the preprint server for biology (2024)
Nature Communicationsno. 1 (2023): 1-17
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GENOME RESEARCHno. 8 (2023): 1258-1268
Cell Genomicsno. 10 (2023): 100404-45
BIOINFORMATICS ADVANCESno. 1 (2023): vbad152-vbad152
Kathleen S.M. Reed,Eric S. Davis,Marielle L. Bond,Alan Cabrera,Eliza Thulson,Ivana Yoseli Quiroga, Shannon Cassel, Kamisha T. Woolery,Isaac Hilton,Hyejung Won,Michael I. Love,Douglas H. Phanstiel
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