In my laboratory, we develop animal models for aerosol exposure to infectious agents (viruses and bacteria) that cause severe acute disease when inhaled. We use the world-class Aero3G aerosol management platform that offers maximum flexibility in choice of aerosol generators, sampling devices, and exposure chambers. Using a custom class III biological safety cabinet, we can safely expose animals to aerosols containing pathogenic agents. We can perform aerosol exposures on rodents, ferrets, rabbits, and nonhuman primates (both Old and New World species). In addition, we use radiotelemetry to study the physiological response to infection (e.g., fever, ECG, EEG). We use these models to study the disease course and pathogenesis, as well as evaluate vaccines or drugs against these agents.