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Research Summary:
To date, our group has established COPD as an inflammatory lung condition with significant extrapulmonary complications such as cardiovascular disease. We have also shown that certain proteins in peripheral circulation are good biomarkers to predict which COPD patients will develop cardiovascular complications. One such biomarker is myeloperoxidase (MPO). We have shown using a large epidemiological study that serum MPO is a robust predictor of cardiovascular mortality. We have also shown that acute lung inflammation induces expression of MPO in both lungs and atherosclerotic plaques. We now have a murine model which will enable studies to determine whether MPO has a direct role in the pathogenesis of atheroclerotic plaque rupture.
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论文共 1056 篇作者统计合作学者相似作者
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COPDno. 1 (2024): 1-11
Juan Carlos Hernaiz-Leonardo, Changwan Ryu, Athenea Pascual,Judy Fan, Maria Caray,Rogério Pezato,Julia Yang,Don Sin,Andrew Thamboo
International forum of allergy & rhinology (2024)
Rachel L Eddy,David Mummy, Shuo Zhang, Haoran Dai, Aryil Bechtel, Alexandra Schmidt, Bradie Frizzell,Firoozeh V Gerayeli,Jonathon A Leipsic,Janice M Leung,Bastiaan Driehuys,Loretta G Que,
The European respiratory journal (2024)
Expert review of molecular diagnostics (2024)
Nathaniel M. Hawkins,Clementine Nordon,Kirsty Rhodes, Manisha Talukdar,Suzanne Mcmullen, Paul Ekwaru, Tram Pham, Arsh K. Randhawa,Don D. Sin
HEART (2024)
Belal Tafech, Mohammad-Reza Rokhforouz,Jerry Leung, Molly Mh Sung,Paulo Jc Lin,Don D Sin, Daniel Lauster, Stephan Block,Bradley S Quon,Ying Tam,Pieter Cullis, James J Feng,
Advanced healthcare materialspp.e2304525-e2304525, (2024)
CURRENT OPINION IN PULMONARY MEDICINEno. 2 (2024): 121-128
The European respiratory journal (2024)
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