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A05 - MITOCHONDRIAL DYNAMICS IN MACROPHAGES IN RESPONSE TO FATTY ACIDS
Mitochondrial metabolism is a recognized regulator of macrophage polarization. In the next funding period, we would like to elucidate the mechanisms of mitochondrial fragmentation by fatty acids. We examine whether mitochondrial decoupling and the altered composition of mitochondrial lipids are central to fragmentation. Furthermore, we clarify the role of mitochondrial fragmentation in the pro-inflammatory responses of macrophages in vitro as well as in mouse models of insulin resistance. Third, we would like to clarify the role of fatty acid-induced mitochondrial fragmentation in mitophagy, as well as the influence of AMP-activated protein kinase on fragmentation.
Mitochondrial metabolism is a recognized regulator of macrophage polarization. In the next funding period, we would like to elucidate the mechanisms of mitochondrial fragmentation by fatty acids. We examine whether mitochondrial decoupling and the altered composition of mitochondrial lipids are central to fragmentation. Furthermore, we clarify the role of mitochondrial fragmentation in the pro-inflammatory responses of macrophages in vitro as well as in mouse models of insulin resistance. Third, we would like to clarify the role of fatty acid-induced mitochondrial fragmentation in mitophagy, as well as the influence of AMP-activated protein kinase on fragmentation.
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Frontiers in Immunology (2023): 1180488
biorxiv(2022)
Felix F Lillich,Sabine Willems,Xiaomin Ni,Whitney Kilu, Carmen Borkowsky, Mirko Brodsky,Jan S Kramer,Steffen Brunst,Victor Hernandez-Olmos,Jan Heering,Simone Schierle, Roxane-I Kestner,
FRONTIERS IN IMMUNOLOGY (2021): 632526-632526
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