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个人简介
Research Interests: Neuropathology and Biomarkers of Neurodegenerative Disease.
Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.
Research Details: In the Penn Digital Neuropathology Lab (DNPL), we use a multidisciplinary approach merging techniques in "wet-lab" based histopathology of human brain tissue with "dry-lab" based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
研究兴趣
论文共 482 篇作者统计合作学者相似作者
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Neurologyno. 4 (2024): e208033-e208033
Aaron Baldwin, Juliette Copeland, Meron Azage,Laynie Dratch,Kelsey Johnson,Rachel A Paul, Defne A Amado,Michael Baer,Andres Deik,Lauren B Elman,Michael Guo,Ali G Hamedani,
Laynie Dratch, Meron Azage,Aaron Baldwin,Kelsey Johnson,Rachel A. Paul,Tanya M. Bardakjian, Sara-Claude Michon,Defne A. Amado,Michael Baer,Andres F. Deik,Lauren B. Elman,Pedro Gonzalez-Alegre,
Journal of Neurologyno. 2 (2024): 733-747
Xueying Lyu,Michael Tran Duong,Long Xie,Robin de Flores,Hayley Richardson,Gyujoon Hwang, Laura E. M. Wisse, Michael Dicalogero,Corey T. Mcmillan,John L. Robinson,Sharon X. Xie,Edward B. Lee,
ALZHEIMERS & DEMENTIAno. 3 (2024): 1586-1600
George T Kannarkat,Rebecca Zack, R Tyler Skrinak,James F Morley, Roseanne Davila-Rivera,Sanaz Arezoumandan, Katherine Dorfman,Kelvin Luk,David A Wolk,Daniel Weintraub,Thomas F Tropea,Edward B Lee,
crossref(2024)
arxiv(2023)
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medRxiv : the preprint server for health sciences (2023)
PEC Innovation (2023): 100108-100108
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