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Research
The research of the Biotransformation and Biocatalysis group is aimed at obtaining insight in the enzymology of the microbial transformation of synthetic compounds, and the development of improved biocatalysts for such transformations. We study catalytic mechanisms, kinetic properties, and structure-function relationships in enzymes that can be used for regio- and enantioselective synthesis reactions for preparing fine chemicals. Obtaining new enzymes by enrichment, genome mining, and high-throughput screening as well as their improvement by structure-based protein engineering and directed evolution are important parts of this work. Computational approaches are increasingly used to improve enzyme stability and selectivity. Applications are developed in various programs with external partners.
研究兴趣
论文共 476 篇作者统计合作学者相似作者
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Nikolas Capra, Chloé Lelièvre, Océane Touré,Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire,Dick B. Janssen,Andy-Mark W. H. Thunnissen,Anne Zaparucha
Frontiers in Catalysis (2024)
The FEBS journalno. 20 (2023): 5016-5035
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Frontiers in Catalysis (2022)
biorxiv(2021)
Antonija Marjanovic, Henriëtte J. Rozeboom, Meintje S. Vries, Clemens Mayer, Marleen Otzen, Hein J. Wijma, Dick B. Janssen
crossref(2021)
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