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From her early work, Dr. Diane Re has been interested in studying the cells called astrocytes, which normally support neuronal survival and transmission and whose importance in the brain is increasingly recognized. Dr. Re did her post-doctoral training at Columbia University under the mentorship of Prof. Serge Przedborski. There, she acquired extensive experience in neurodegeneration and in the adult-onset paralytic disorder Amyotrophic Lateral Sclerosis (ALS). Notably, her work pioneered the notion that in ALS motor neurons are degenerating due to the development of a hostile cellular environment. In particular, astrocytes undergo a transformation from benign supportive cells into potent motor neuron killers. Thereafter, she followed her interest in developing models of the sporadic form of ALS, which account for 90% of cases and may have a strong environmental component. On the basis of this effort in 2010, Dr. Re received a Career Development Award from the NIEHS Center of Northern Manhattan, which helped her to develop the first entirely humanized in vitro model of sporadic ALS by using cells directly produced from patients. More recently, using this in vitro model, Dr. Re and Dr. Guilarte have identified that translocator protein, TSPO, is a potential therapeutic target for motor neuron degeneration in ALS. Hypothesis that she is now testing thanks to a Department of Defense grant. Lately, Dr. Re obtained a Pilot Project Grant from the NIEHS Center of Northern Manhattan to examine another possible environmental trigger of motor neuron degeneration, the industrial metal manganese. Dr. Re is also developing some research work on the potential involvement of pesticides in ALS and dementia. Dr. Re's overarching goal is to unravel the potential environmental/occupational origins of neurodegenerative diseases and the importance of gene-environment interactions in their pathogenesis.
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American journal of epidemiologyno. 9 (2023): 1499-1508
Journal of Cachexia, Sarcopenia and Muscleno. 3 (2023): 1322-1336
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EPIDEMIOLOGYno. 6 (2022): 757-766
Journal of clinical and translational scienceno. s1 (2022): 63-64
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