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Diana W. Bianchi is an American medical geneticist and neonatologist noted for her research on fetal cell microchimerism and prenatal testing. Bianchi is currently the Natalie V. Zucker Professor of Pediatrics, Obstetrics, and Gynecology at Tufts University School of Medicine and Executive Director of the Mother Infant Research Institute at Tufts Medical Center. She is also Vice Chair for Research in the Department of Pediatrics at the Floating Hospital for Children at Tufts Medical Center.
Bianchi grew up in New York City.
She earned a B.A. from University of Pennsylvania and an M.D. from Stanford University School of Medicine. While at Stanford she performed her doctoral research with Leonard Herzenberg, Ph.D., studying the use of flow cytometry to develop a noninvasive cytogenetic prenatal diagnostic test for Down syndrome. One of Herzenberg’s children had Down syndrome, so the project had both scientific and personal significance for her mentor.[1] She completed her postdoctoral work at Boston Children’s Hospital and Harvard Medical School.
She is a member of the Clinical Advisory Board of Verinata Health, an Illumina company.[2] Bianchi is one of four authors of the book Fetology: Diagnosis and Management of the Fetal Patient.[3] This book won the Association of American Publishers award for the best textbook in clinical medicine in 2000. Bianchi joined the faculty at Harvard University in 1986, concurrently assuming a position as an attending neonatologist and geneticist at Boston Children’s Hospital. In 1993, Bianchi left to take a position at Tufts University School of Medicine, receiving an endowed chair in 2002.
In 2007, Bianchi became Editor-in-Chief of Prenatal Diagnosis, the official journal of the International Society for Prenatal Diagnosis.[4] In 2010, she founded the Mother Infant Research Institute (MIRI) at Tufts Medical Center, assuming the position of Executive Director.[5]
Bianchi worked for many years on developing methods to isolate intact fetal cells from maternal blood as a noninvasive way to obtain fetal material for genetic diagnosis. While the work proved challenging due to the relative rarity of the fetal cells in the mother’s blood, the research led to an unexpected finding. Bianchi discovered that intact fetal cells remain in the mother's blood and organs for decades following pregnancy, with the possibility of migrating to the site of an injury in the mother, dividing and changing into the cells needed to fix the problem.[6][7][8] This has led to a field of study known as fetal cell microchimerism.
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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGYno. 2 (2024)
Diana W. Bianchi, Patricia Flatley Brennan, Michael F. Chiang, Lindsey A. Criswell, Rena N. D’Souza,Gary H. Gibbons, James K. Gilman,Joshua A. Gordon,Eric D. Green, Susan Gregurick,Richard J. Hodes, Peter H. Kilmarx,
Nature Medicineno. 2 (2024): 330-333
American journal of medical genetics. Part App.e63583-e63583, (2024)
Marisa E Schwab,Billie R Lianoglou,Dawn Gano,Juan Gonzalez Velez,Isabel E Allen, Regina Arvon,Ahmet Baschat,Diana W Bianchi,Melissa Bitanga, Anne Bourguignon,Richard N Brown,Bruce Chen,
Prenatal Diagnosisno. 9 (2023): 1101-1109
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Springer eBookspp.333-355, (2023)
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATIONno. 18 (2023): 1729-1729
Journal of neuroscience researchno. 4 (2023): 492-507
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