基本信息
浏览量:0
职业迁徙
个人简介
Research Interests
Our somatosensory system enables numerous behaviors fundamental to human existence, allowing us to eat, communicate and survive. Acute pain is as a warning signal that alerts us to noxious mechanical, chemical and thermal stimuli, which are potentially tissue damaging. During inflammation or injury, we experience a heightened sensitivity to touch that encourages us to protect the injured site. Despite this essential protective function, pain can outlast its usefulness and become chronic. Numerous pathophysiological conditions result in the chronic dysregulation of mechanosensory signaling, leading to pain triggered by light touch (allodynia), as well as enhanced sensitivity to noxious mechanical stimuli.
Light-touch receptors, which mediate discriminative touch, enables fine tactile acuity that allows us to manipulate objects with high precision. As humans, we depend on this skill for everyday tasks that range from eating with utensils to texting. Discriminative touch is also central to social interactions such as mating, maternal bonding and successful child rearing.
To understand the senses of touch and pain, we must unravel peripheral mechanisms that encode tactile stimuli and discover how the brain interprets these signals to dictate behavior. The transduction of a physical force on the skin into an electrical signal is the first step in the encoding of tactile stimuli. My group uses molecular biology and cellular physiology to discover the ransduction molecules that underlie touch.
Our somatosensory system enables numerous behaviors fundamental to human existence, allowing us to eat, communicate and survive. Acute pain is as a warning signal that alerts us to noxious mechanical, chemical and thermal stimuli, which are potentially tissue damaging. During inflammation or injury, we experience a heightened sensitivity to touch that encourages us to protect the injured site. Despite this essential protective function, pain can outlast its usefulness and become chronic. Numerous pathophysiological conditions result in the chronic dysregulation of mechanosensory signaling, leading to pain triggered by light touch (allodynia), as well as enhanced sensitivity to noxious mechanical stimuli.
Light-touch receptors, which mediate discriminative touch, enables fine tactile acuity that allows us to manipulate objects with high precision. As humans, we depend on this skill for everyday tasks that range from eating with utensils to texting. Discriminative touch is also central to social interactions such as mating, maternal bonding and successful child rearing.
To understand the senses of touch and pain, we must unravel peripheral mechanisms that encode tactile stimuli and discover how the brain interprets these signals to dictate behavior. The transduction of a physical force on the skin into an electrical signal is the first step in the encoding of tactile stimuli. My group uses molecular biology and cellular physiology to discover the ransduction molecules that underlie touch.
研究兴趣
论文共 86 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Sonali S Mali, Ricardo Silva,Zhongyan Gong,Michael Cronce, Uyen Vo, Cliff Vuong, Yalda Moayedi,Jeffery S Cox,Diana M Bautista
bioRxiv : the preprint server for biology (2024)
Jiro Yoshino, Sonali Mali,Claire Williams,Takeshi Morita, Chloe Emerson,Christopher Arp,Sophie Miller,Chang Yin,Lydia The, Hemmi Chikaya,Mana Motoyoshi,Kenichi Ishii,
biorxiv(2024)
引用0浏览0WOS引用
0
0
Jiro Yoshino,Sonali Mali,Claire Williams,Takeshi Morita, Clifton W. Emerson,Christopher D. Arp,Miller Sophie,Chang Yin,Lydia The, Hemmi Chikaya,Mana Motoyoshi,Kenichi Ishii,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
引用0浏览0引用
0
0
bioRxiv : the preprint server for biologypp.1-33, (2021)
Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong,Zihe Zhang,Diana M. Bautista,Clifford J. Woolf
Cellno. 2 (2021): 294-296
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn