Dr. Dhir's interests include the molecular changes in bladder, renal and prostate carcinogenesis. The Pittsburgh GU group has an ongoing research study evaluated RNA expression, SNP, micro-RNA and proteomic perturbations to get a global integrated view of disease onset and progression. Current research focuses on translation of some of the discoveries into validated, clinically relevant tests. There is also ongoing work on correlative work aimed at sub-cellular changes and their correlation with response to different treatment modalities and assessment of chemo-preventive approaches.