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职业迁徙
个人简介
I have several years of experience in the areas of Molecular biology, Cancer Biology, Virology, cytokine-induced innate immunity, Signal transduction, autophagy, and transcriptional regulation of gene expression. My seminal contributions include the discovery of GRIMs, a novel group of tumor suppressor genes; novel cytokine inducible gene regulatory elements, their cognate transcription factors and signal transduction pathways that control them. I am also one of the first few investigators who described mechanisms of viral resistance to Interferon actions. I have developed the concept of GRIMs and identified the critical genes involved in this process. My lab was the first to describe GRIM-19, a novel tumor suppressor, monoclonal antibodies against it, its interacting proteins, functionally inactivating somatic mutations, loss of expression in primary human tumors. We have also developed conditional knockout mouse models that allow the study of tumor suppressors and oncogenes. We were also one of first group to apply genome-wide expression knockdown technologies before the description of whole genome sequences and RNAi technology.
研究兴趣
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biorxiv(2020)
semanticscholar(2018)
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