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Demetrios A. Spandidos is Professor of Virology (since
1989) at the Medical School, University of Crete, Director of
Clinical Virology, Clinical Bacteriology, Parasitology,
Zoonoses and Geographical Medicine Laboratories at the
University Hospital and the Medical School in Heraklion, Crete
and he was Research Professor and Director of the Laboratory
of Molecular Oncology and Biotechnology (1988-1998) at
the Institute of Biological Research and Biotechnology at the
National Hellenic Research Foundation in Athens, Greece.
He is the founder and Editor of the International Journal of
Oncology, Oncology Reports and International Journal of
Molecular Medicine.
Dr Spandidos was born in Agios Constantinos, Sparta,
Greece and obtained his B.Sc. in Chemistry from the University
of Thessaloniki, Greece in 1971, a Ph.D. in Biochemistry
from McGill University in Montreal, Canada in 1976 and a
D.Sc. in Genetics from the University of Glasgow, UK in
1989. He is Fellow of the Royal Society of Health (1994)
London, UK, Fellow of the Royal College of Pathology
(1997) London, UK, Awarded the specialty of Clinical
Chemistry, Greece (1998), Fellow of the American Society
of Angiology (2005), Doctor Honoris Causa of the ‘Carol
Davila’, University of Medicine and Pharmacy, Bucharest and
of the ‘Iuliu Hatieganu’ University of Medicine and Pharmacy,
Cluj-Napoca, Romania, Visiting Professor of the University of
Catania, Italy, and corresponding Member of the Academia
National de Medicina de Buenos Aires, Argentina (1999).
He was an MRC of Canada post-doctoral Fellow at the
Department of Medical Genetics at the University of Toronto in
1976-1978, an Assistant Professor (Epimelitis) at the Hellenic
Anticancer Institute in Athens in 1978-1979, an MRC of
Canada Centennial Fellow at the Beatson Institute for Cancer
Research in Glasgow in 1979-1981 and a member of the Senior
Scientific Staff at the Beatson Institute for Cancer Research
from 1981-1989 when he took up his present appointments in
Greece.
The identification of cellular oncogenes has probably been
the most important discovery in modern cancer research. Prior
to their isolation and identification as cellular homologues of
retroviral transforming genes, many scientists believed that
highly transforming retroviruses and their oncogenes were
experimental artifacts irrelevant to human cancer. Since then an
explosion of work has demonstrated the direct relevance of
cellular oncogenes to cancer development, diagnosis and
treatment. This depended on technical and conceptual advances
in the identification of cellular oncogenes and analysis of their
role in multistage carcinogenesis. Dr Spandidos has made
extremely important and perhaps unique contributions in these
fields.
Dr Spandidos was the first scientist in the field of oncology
to develop and apply the gene transfer technique, which has
become a most potent tool to investigate oncogenes (D.A.
Spandidos and L. Siminovitch, Cell 12: 675-682, 1977; D.A.
Spandidos and L. Siminovitch, Nature 271: 259-261, 1978)
(for a more detailed account see Spandidos DA, The cancer
story, Cancer Biology and Therapy 3: 1184-1186, 2004).
Thus, his work assisted in development of the gene transfer
technology that has been of paramount importance in revealing
new oncogenes, as well as implementing the molecular understanding
of oncogenes and how the normal proto-oncogenes
become activated into their malignant transforming cognates.
This field has expanded tremendously over the past thirty
years and Dr Spandidos has continued to contribute actively,
playing a major role in scientific investigations on the ras
oncogenes. While at the Beatson Institute for Cancer Research
in Glasgow he performed notable and important investigations
on the nature of transformation of normal cells by introduction
of single ras genes using retroviral LTRs and other strong
promoters (D.A. Spandidos and N.M. Wilkie, Nature 310:
469-475, 1984; cited over 510 times). Some other ideas of
his were very provocative at the time like the dual function of
ras genes as oncogenes and onco-suppressors (D.A. Spandidos
and N.M. Wilkie, Br J Cancer 58: 67, 1988) which have now
proven to be correct (D.A. Spandidos, et al, Int J Oncol 21:
237-241, 2002). His most significant work includes the discovery
of avian reovirus (D.A. Spandidos and A.F. Graham,
J Virol 19: 977, 1976 - more than 75 citations), the transfer of
human globin genes to hemopoietic cells (D.A. Spandidos
and J. Paul, EMBO J 1: 15, 1982 - more than 65 citations), the
involvement of ras genes in colon tumours (D.A. Spandidos
and I.B. Kerr, Br J Cancer 49: 681, 1984 - more than 210
citations), the role of ras and myc genes in apoptosis (A.H.
Wyllie, K.A. Rose, R.G. Morris, C.M. Steel, E. Foster and
D.A. Spandidos, Br J Cancer 56: 251, 1987 - more than 190
citations), the involvement of c-myc (J.K. Field, D.A.
Spandidos, et al, Oncogene 4: 1463, 1989 - more than 115
citations) and p53 (J.K. Field, D.A. Spandidos, et al, Br J
Cancer 64: 573, 1991 - more than 250 citations) in head and
neck carcinomas. Dr Spandidos is the most highly cited
scientist in all sciences for work performed in Greece.
Dr Spandidos has organized 31 international meetings
on a variety of areas of oncology and molecular medicine
and he has served on the Editorial Boards of a number of
journals and he is an Honorary Member of several societies.
Dr Spandidos has authored more than 450 publications, 700
communications and invited talks at international conferences
and his work has received over 7000 citations. Although
actively occupied in fundamental studies in cell and molecular
oncology he has always been ready to explore the medical
implications of his work with colleagues in the pathological and
clinical sciences and has stimulated work in many different
laboratories throughout the world. Part of his efforts has been to
establish a scientific tradition in biomedical sciences in Greece,
including the successful creation of a school of talented
scientists with international recognition. As a result of the
efforts of Dr Spandidos Greece has been put on the map of
biomedical and cancer research at an international level. For
full details of Professor D.A. Spandidos' achievements and a
list of publications see www.spandidos.com.
研究兴趣
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Maria I. Zervou,Basil C. Tarlatzis,Grigoris F. Grimbizis,Demetrios A. Spandidos, Timothy B. Niewold,George N. Goulielmos
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINEno. 2 (2024)
Maria I Zervou,Basil C Tarlatzis,Grigoris F Grimbizis,Demetrios A Spandidos, Timothy B Niewold,George N Goulielmos
International journal of molecular medicineno. 2 (2024)
International journal of molecular medicineno. 5 (2023)
Biomedical reportsno. 1 (2023): 48
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Fotios Kakridonis, Spyros G Pneumatikos,Elena Vakonaki,Aikaterini Berdiaki,Manolis N Tzatzarakis,Persefoni Fragkiadaki,Demetrios A Spandidos,Stella Baliou, Petros Ioannou,Eleftheria Hatzidaki,Dragana Nikitovic,Aristidis Tsatsakis,
Biomedical reportsno. 5 (2023): 87
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Medicine internationalno. 3 (2023): 23-23
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Iason-Stefanos Anagnostopoulos,Vasiliki Epameinondas Georgakopoulou, Ilias Trakas,Petros Papalexis,Nikolaos Trakas,Demetrios A Spandidos,George Fotakopoulos
Experimental and therapeutic medicineno. 2 (2023): 377
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Antonios A Papadakis, Ioannis Tsirigotakis, Sofia Katranitsa, Christos Donousis,Petros Papalexis,Dimitrios Keramydas, Elias Chaidoutis,Vasiliki Epameinondas Georgakopoulou,Demetrios A Spandidos,Theodoros C Constantinidis
Medicine internationalno. 4 (2023): 32
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