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The proliferative state of normal cells is precisely regulated by signals received from the extracellular environment. Understanding how these signals are relayed from the cell surface to the nucleus is the major objective of the Cellular Growth Mechanisms Section. Studies in this area are particularly relevant to cancer research because release from regulatory controls at any point along the signaling cascade can result in uncontrolled cell growth or oncogenesis. We have chosen to focus our studies on the pathway regulated by the Ras GTPase, where our aims are to further elucidate the processes involved in signal transduction and to identify critical regulatory points linked to tumor formation.
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Biochemical Society transactions (2024)
Christian William Johnson,Elizabeth M. Terrell, Josh Cook,Bing Shui, Eve O'Donoghue, Shannon Hull,Moon Hee Yang, Shikha Sheth, Rona Yaeger,Scott Kopetz,Deborah K. Morrison,Kevin Haigis
Cancer Researchno. 6_Supplement (2024): 6623-6623
Joshua T. Kowalczyk,Xiaolin Wan, Edjay R. Hernandez,Ruibai Luo,Gaelyn C. Lyons,Kelli M. Wilson, Devorah C. Gallardo, Kristine A. Isanogle,Christina M. Robinson,Arnulfo Mendoza,Christine M. Heske, Jinqui-Qiu Chen,
crossref(2023)
crossref(2023)
Molecular Cancer Researchno. 5_Supplement (2023): PR06-PR06
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James V. Neiswender,Robert L. Kortum, Caitlin Bourque,Melissa Kasheta,Leonard I. Zon,Deborah K. Morrison, Craig J. Ceol
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