Dr. Citrin’s clinical and laboratory research focus on two main themes: 1) predicting which tumors are resistant to killing by radiation, and in turn, targeting these tumors more effectively with novel drug radiation combinations, and 2) understanding the mechanisms of normal tissue injury from radiation. Dr. Citrin is particularly interested in developing strategies to enhance the capacity of radiation to kill tumor cells while protecting normal tissue from the side effects of radiation treatment. Much of her laboratory work has focused on aging in tissue exposed to radiation through stem cell senescence.