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个人简介
About Dr. Marks: I am a computational biologist interested in how to read the genome and interpret its variation. Recently, we have used evolutionary couplings determined from genomic sequencing to accurately protein 3D structure from sequences alone, including the experimentally challenging transmembrane proteins. Continuing from this my lab aims to predict alternative conformations and plasticity of proteins, and the consequences of protein genetic variation on pharmacological intervention. In a complementary approach, we are examining on the effect of drugs on patients and cell lines by bringing together large bodies of data from multiple perturbations and thousands of cancer patient tissues.
研究兴趣
论文共 165 篇作者统计合作学者相似作者
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Noor Youssef,Sarah Gurev,Fadi Ghantous,Kelly P. Brock,Javier A. Jaimes,Nicole N. Thadani,Ann Dauphin, Amy C. Sherman,Leonid Yurkovetskiy, Daria Soto, Ralph Estanboulieh,Ben Kotzen,
biorxiv(2024)
David Ding, Ada Y. Shaw, Sam Sinai, Nathan Rollins, Noam Prywes, David F. Savage, Michael T. Laub,Debora S. Marks
Nature Communicationsno. 1 (2024): 1-12
Nicholas Hoppe, Simone Harrison,Sun-Hee Hwang,Ziwei Chen, Masha Karelina,Ishan Deshpande,Carl-Mikael Suomivuori, Vivek R. Palicharla,Samuel P. Berry,Philipp Tschaikner,Dominik Regele,Douglas F. Covey,
Nature Structural & Molecular Biologypp.1-11, (2024)
Nature Biotechnologyno. 2 (2024): 216-228
Benjamin J. Livesey, Mihaly Badonyi,Mafalda Dias,Jonathan Frazer, Sushant Kumar, Kresten Lindorff-Larsen, David M. McCandlish,Rose Orenbuch, Courtney A. Shearer,Lara Muffley,Julia Foreman,Andrew M. Glazer,
arxiv(2024)
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medRxiv : the preprint server for health sciences (2024)
Stefan Peidli, Tessa D. Green,Ciyue Shen, Torsten Gross,Joseph Min,Samuele Garda,Bo Yuan,Linus J. Schumacher,Jake P. Taylor-King,Debora S. Marks, Augustin Luna,Nils Blüthgen,
Nature Methodsno. 3 (2024): 531-540
Natureno. 7984 (2023): 818-825
Allison Snyder,Veronica H Ryan,James Hawrot, Sydney Lawton,Daniel M Ramos, Y Andy Qi,Kory Johnson,Xylena Reed, Nicholas L Johnson,Aaron W Kollasch,Megan Duffy,Lawren VandeVrede,
Research square (2023)
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