Research in the MacMillan Group is centered on the field of organic synthesis and catalysis. We are inspired by the pursuit of new concepts in synthetic organic chemistry that allow access to structural and stereochemical motifs not readily available using conventional methods. In this endeavor, we target the development of general strategies that can be implemented in a wide spectrum of chemical processes. We place particular emphasis on the synthesis of moieties prevalent in medicinal agents, agrochemicals and natural products, with the goal of streamlining existing synthetic routes and facilitating the discovery of new bioactive scaffolds.