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His research comprises, the molecular mechanisms by which Bcl-2 family proteins regulate apoptosis, early stage drug discovery, high-content screening and development of new microscopes for fluorescence lifetime imaging microscopy (FLIM) and hyperspectral imaging. Dr. Andrews’ lab uses fluorescence spectroscopy and fluorescence spectroscopic microscopy to study interactions between proteins in membranes using purified proteins, and in live cells. To study cancer, they use primary patient cells grown as 3D organoids for drug screening. At SRI, he has established a facility for image-based high-content cellular analysis that includes instrumentation for automated imaging and analysis of cells in monolayer and 3D cultures, genome scale gene knockdown and screening of libraries of small molecules. In early stage drug discovery research, his lab has identified and characterized small molecules that have applications to cancer and regenerative medicine.
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Cancer Researchno. 6_Supplement (2024): 231-231
CANCER RESEARCHno. 7 (2023)
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Acta Neurochirurgicano. 12 (2023): 4175-4182
Cancer Researchno. 11_Supplement (2023): B073-B073
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Diandra Zipinotti dos Santos,Mohamad Elbaz, Emily Branchard, Wiebke Schormann,David W. Andrews,Linda Z. Penn
CANCER RESEARCHno. 11 (2023)
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Martin Cottet, Yuniel Fernandez Marrero, Simon Mathien, Karine Audette, Raphaelle Lambert, Eric Bonneil, Kenneth Chng, Alex Campos,David W. Andrews
SLAS Discoveryno. 3 (2023): 100121
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): e14570-e14570
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