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个人简介
David Breault’s research focuses on understanding the hormonal regulation of stem cells and their lineage development. His laboratory is focused on identifying mechanisms underlying tissue homeostasis in self-renewing tissues, such as intestine, adrenal gland, bone.
The Breault lab is investigating telomerase expression as a biomarker for self-renewing progenitor/stem cells. Their efforts have led to the generation of mTert-reporter mice and the discovery of several populations of slowly-cycling tissue stem cells, including an elusive intestinal stem cell. Ongoing efforts are aimed at characterizing stem cell responses to physiological and pathological stress and age with the ultimate goal to improve therapeutic treatment options for a wide range of conditions.
The Breault lab is investigating telomerase expression as a biomarker for self-renewing progenitor/stem cells. Their efforts have led to the generation of mTert-reporter mice and the discovery of several populations of slowly-cycling tissue stem cells, including an elusive intestinal stem cell. Ongoing efforts are aimed at characterizing stem cell responses to physiological and pathological stress and age with the ultimate goal to improve therapeutic treatment options for a wide range of conditions.
研究兴趣
论文共 170 篇作者统计合作学者相似作者
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EBIOMEDICINE (2024): 104921-104921
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Luiz Fernando Silva Oliveira, Comfort Adegboye, Venkata Siva Dasuri, Wanshu Qi,Radhika S. Khetani,Akaljot Singh, Nambirajam Sundaram, Jasmine Lin, Prathima Nandivada, Lorena Rincón-Cruz,
Cellular and Molecular Gastroenterology and Hepatology (2024)
Jani Liimatta, Evelyn Curschellas,Emre Murat Altinkilic,Rawda Naamneh Elzenaty, Philipp Augsburger,Therina du Toit, Clarissa D. Voegel,David T. Breault,Christa E. Flueck,Emanuele Pignatti
Taciani de Almeida Magalhaes, Jingjing Liu,Charlene Chan,Kleiton Silva Borges,Jiuchun Zhang,Andrew J. Kane,Bradley M. Wierbowski, Yunhui Ge, Zhiwen Liu,Prabhath Mannam,Daniel Zeve,Ron Weiss,
DEVELOPMENTAL CELLno. 2 (2024): 244-+
Endocrinologyno. 5 (2024)
Jianbo Zhang,Yu-Ja Huang,Martin Trapecar,Charles Wright,Kirsten Schneider, John Kemmitt,Victor Hernandez-Gordillo, Jun Young Yoon,Mathilde Poyet,Eric J Alm,David T Breault,David L Trumper,
NPJ biofilms and microbiomesno. 1 (2024): 31-31
Cancer researchno. 13 (2023): 2123-2141
引用3浏览0WOS引用
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GASTROENTEROLOGYno. 6 (2023): S97-S98
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Xiaofeng Huang,Wei Gu,Jiaoyue Zhang,Ying Lan, Jonathan L. Colarusso,Sanlan Li, Christoph Pertl,Jiaqi Lu,Hyunkee Kim,Jian Zhu,David T. Breault,Jean Sévigny,
Nature cell biologyno. 5 (2023): 778-786
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