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His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.
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论文共 482 篇作者统计合作学者相似作者
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JOURNAL OF NEURO-OPHTHALMOLOGYno. 1 (2024): 16-21
Patrick T. Griffin,Alice E. Kane,Alexandre Trapp, Jien Li, Matthew Arnold,Jesse R. Poganik, Ryan J. Conway, Maeve S. McNamara,Margarita V. Meer, Noah Hoffman,João A. Amorim,Xiao Tian,
Nature Agingno. 2 (2024): 261-274
CELL METABOLISMno. 2 (2024): 354-376
Andrea Cipriano,Mahdi Moqri,Sun Y. Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, Alexander Parker, Sajede Rasouli,Hans Robert Schöler,David A. Sinclair,Vittorio Sebastiano
Nature Agingno. 2 (2024): 275-275
Cellno. 5 (2024): 1103-1105
Andrea Cipriano,Mahdi Moqri, Sun Y. Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, Alexander Parker, Sajede Rasouli, Hans Robert Schöler,David A. Sinclair,Vittorio Sebastiano
Bruce Ksander,Madhura Shah,Drenushe Krasniqi,Meredith S. Gregory-Ksander, Sharon Rosenzweig-Lipson, Kasia Broniowska,Michel Wathier,Joan Mannick, Jennifer Cermak,Margarete Karg,Shintaro Shirahama,Nasrin Refaian,
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Nicola Boekstein,Nir Barzilai, André Bertram, Joe Betts-LaCroix,Kristen Fortney, Stephen B. Helliwell, Michael Hufford,Joan Mannick, Jerry McLaughlin, Jim Mellon, Eric Morgen,Nils Regge,
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