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Dr. Schrump oversees clinical and translational research pertaining to thoracic malignancies, including the development of innovative molecular approaches to the diagnosis and treatment of these neoplasms. He has pioneered the development of epigenomic therapies for thoracic cancers. Using unique in vitro models and correlative experiments with surgical specimens, he has characterized epigenetic responses to tobacco carcinogens, and identified novel therapeutic targets in lung and esophageal cancers and pleural mesotheliomas. His clinical protocols have demonstrated that chromatin remodeling agents simultaneously induce growth arrest and augment immunogenicity of thoracic malignancies; these efforts have provided rationale for combining epigenetic regimens with immunotherapies for these neoplasms.
研究兴趣
论文共 287 篇作者统计合作学者相似作者
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CANCERSno. 4 (2024): 702
Vivek Shukla, Haitao Wang, Lyuba Varticovski, Songjoon Baek, Ruihong Wang, Xinwei Wu, Frank Echtenkamp, Frank Villa Hernandez, Katherine P. Prothro, Sudheer K. Gara, Mary R. Zhang, Stephanie Shiffka,
LUNG CANCER (2024): 107473-107473
Shingo Inaguma, Chengbo Wang, Sunao Ito, Akane Ueki,Jerzy Lasota,Piotr Czapiewski,Renata Langfort,Janusz Rys, Joanna Szpor, Piotr Waloszczyk,Krzysztof Okoń,Wojciech Biernat,
Pathobiology : journal of immunopathology, molecular and cellular biology (2024)
Aaron J. Dinerman, Alexandra M. Gustafson,Ali T. Elsaadi,Donald White,David S. Schrump,Chuong D. Hoang,Jonathan M. Hernandez,Mei Li Kwong,James C. Yang,Stephanie Goff,Steven A. Rosenberg, Nicholas D. Klemen
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Frank Villa Hernandez, Umay Tuana Tolunay,Lindsay A. Demblowski,Haitao Wang,Shamus R. Carr,Chuong D. Hoang,Hyoyoung Choo-Wosoba,Seth M. Steinberg,Martha A. Zeiger,David S. Schrump
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 1 (2024): 271-280.e4
Ruihong Wang,Haitao Wang, Xinwei Wu, Keerti Mishra, Stephanie Shiffka, Frank Hernandez,Mary Zhang, Umay Tuana Tolunay,Sudheer Gara,Sichuan Xi,Shamus R. Carr, Choung D. Hoang,
Cancer Researchno. 6_Supplement (2024): 410-410
Sichuan Xi, Xinwei Wu,David M Straughan,Eden C Payabyab,Haitao Wang, Ruihong Wang,Mary Zhang,Shamus R. Carr,Chuong D. Hoang,David S. Schrump
Cancer Researchno. 6_Supplement (2024): 7545-7545
Sudheer Kumar Gara,Haitao Wang,Anand Singh, Tuana Tolunay, Vivek Shukla, Ruihong Wang,Mary Zhang, Stephanie Shiffka,David S. Schrump
Cancer Researchno. 6_Supplement (2024): 5445-5445
Haitao Wang, Ruihong Wang, Frank Villa-Hernandez, Vivek Shukla,Lyuba Varticovski,Songjoon Baek,Frank Echtenkamp,Sudheer Kumar Gara,Mary R. Zhang, Stephanie Shiffka,Razi Raziuddin,Leonard M. Neckers,
Cancer Researchno. 6_Supplement (2024): 7544-7544
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