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David R. Borchelt

Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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Papers153 papers

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Novel SOD1 Monoclonal Antibodies against the Electrostatic Loop Preferentially Detect Misfolded SOD1 Aggregates

Yuxing Xia, Zhijuan Chen,Guilian Xu,David R Borchelt,Jacob I Ayers,Benoit I Giasson

Neuroscience letters, (2020): 135553

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IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis

Michael R Strickland, Kristen R Ibanez, Mariya Yaroshenko, Carolina Ceballos Diaz,David R Borchelt,Paramita Chakrabarty

Scientific reports, no. 1 (2020): 20862

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Subcellular diversion of cholesterol by gain- and loss-of-function mutations in PMP22

Ye Zhou,David Borchelt, Jodi C Bauson,Sergio Fazio, Joshua R Miles,Hagai Tavori,Lucia Notterpek

Glia, (2020)

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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease

Tosha Williams,David R Borchelt,Paramita Chakrabarty

Molecular Neurodegeneration, no. 1 (2020): 1-19

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Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Jacob I Ayers,David R Borchelt

Acta Neuropathologica, pp.1-15, (2020)

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Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Guilian Xu,Susan E Fromholt,Paramita Chakrabarty, Fanchao Zhu, Xuefei Liu, Michael C Pace, Jin Koh,Todd E Golde,Yona Levites,Jada Lewis,David R Borchelt

Acta Neuropathologica Communications, no. 1 (2020): 1-17

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Anthony Crown, Luke McAlary, Eric Fagerli,Hilda Brown,Justin J Yerbury,Ahmad Galaleldeen,Neil R Cashman,David R Borchelt,Jacob I Ayers

PloS one, no. 1 (2020)

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Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy

Emily J Koller, Elsa Gonzalez De La Cruz, Mary Weinrich, Tosha Williams,Pedro E Cruz, Daniel Ryu,Todd E Golde,Patrick M Sullivan,Jada Lewis,David R Borchelt,Paramita Chakrabarty

Molecular Neurobiology, no. 4 (2020): 1-16

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N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements

M Carolina Gallego-Iradi, Haley Strunk, Anthony M Crown, Rachel Davila,Hilda Brown, Edgardo Rodriguez-Lebron,David R Borchelt

Laboratory investigation; a journal of technical methods and pathology, pp.1, (2019)

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Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Anthony M Crown,Brittany L Roberts,Keith Crosby,Hilda Brown,Jacob I Ayers,P John Hart,David R Borchelt

G3 (Bethesda, Md.), (2019)

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Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

Jess-Karan S Dhillon,Jorge A Trejo-Lopez, Cara Riffe,Yona Levites,Amanda N Sacino,David R Borchelt, Anthony Y Yachnis,Benoit I Giasson

Acta Neuropathologica Communications, no. 1 (2019): 1-13

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PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux

Ye Zhou, Joshua R Miles,Hagai Tavori, Min Lin,Habibeh Khoshbouei,David R Borchelt, Hannah Bazick, Gary E Landreth,Sooyeon Lee,Sergio Fazio,Lucia Notterpek

The Journal of neuroscience : the official journal of the Society for Neuroscience, (2019)

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ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

Zachary Osking,Jacob I Ayers, Ryan Hildebrandt, Kristen Skruber,Hilda Brown, Daniel Ryu, Amanda R Eukovich,Todd E Golde,David R Borchelt, Tracy-Ann Read,Eric A Vitriol

iScience, (2018): 294-304

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Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

Michael C Pace,Guilian Xu,Susan Fromholt,John Howard,Benoit I Giasson,Jada Lewis,David R Borchelt

Molecular neurodegeneration, no. 1 (2018): 23

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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models: Aberrant accrual of BIN1 near AD amyloid deposits

Pierre De Rossi, Robert J. Andrew,Timothy F. Musial,Virginie Buggia-Prevot,Guilian Xu,Moorthi Ponnusamy, Han Ly, Sofia V. Krause, Richard C. Rice, Valentine de l'Estoile, Tess Valin, Someya Salem

Brain Pathology, (2018)

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Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

M Carolina Gallego Iradi, Judy C Triplett,James D Thomas, Rachel Davila, Anthony M Crown,Hilda Brown,Jada Lewis,Maurice S Swanson,Guilian Xu, Edgardo Rodriguez-Lebron,David R Borchelt

Scientific reports, no. 1 (2018): 4049

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Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

Christina Moloney, Sruti Rayaprolu,John Howard,Susan Fromholt,Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy,Zoe Siemienski, Dave Miller,David R Borchelt,Jada Lewis

Acta neuropathologica communications, no. 1 (2018): 137

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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models

Pierre De Rossi, Robert J Andrew, Timothy F Musial, Virginie Buggia-Prevot,Guilian Xu, Moorthi Ponnusamy, Han Ly, Sofia V Krause, Richard C Rice, Valentine de l'Estoile, Tess Valin, Someya Salem

Brain pathology (Zurich, Switzerland), (2018)

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Prion-like Spreading in Tauopathies

Jacob I. Ayers,Benoit I. Giasson,David R. Borchelt

Biological Psychiatry, no. 4 (2018): 337-346

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Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

Keith Crosby, Anthony M. Crown,Brittany Roberts,Hilda Brown,Jacob I. Ayers,David R. Borchelt

bioRxiv, pp.301309-21, (2018)

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