David P. Baccanari

Dlvision of Molecular Genetics and Microbiology Wellcome Research Laboratories, Research Triangle Park, NC 27709, U.S.A.

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ChemInform Abstract: Inhibitors of Dihydrofolate Reductase: Design, Synthesis and Antimicrobial Activities of 2,4-Diamino-6-methyl-5-ethynylpyrimidines

Michael L. Jones,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Lee F. Kuyper

Cheminform, no. 27 (2010)

Bibtex

α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

Shousong Cao,David P Baccanari,Youcef M Rustum,Stephen T Davis,Robert L Tansik,David J.T Porter,Thomas Spector

BIOCHEMICAL PHARMACOLOGY, no. 8 (2000): 953-960

Cited by17EIBibtex

Preclinical Development of Eniluracil: Enhancing the Therapeutic Index and Dosing Convenience of 5-Fluorouracil

Melanie T. Paff,David P. Baccanari,Stephen T. Davis,Shousong Cao,Robert L. Tansik,Youcef M. Rustum,Thomas Spector

Investigational New Drugs, no. 4 (2000): 365-371

Cited by6WOSBibtex

Inhibitors of dihydrofolate reductase: Design, synthesis and antimicrobial activities of 2,4-diamino-6-methyl-5-ethynylpyrimidines

Michael L. Jones,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Lee F. Kuyper

Journal of Heterocyclic Chemistry, no. 1 (1999): 145-148

Cited by2Bibtex

Synthesis of 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]-quinazolines. Inhibitors ofCandida albicansdihydrofolate reductase as potential antifungal agents

Joseph H. Chan,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Andrew D. Brown,Jean S. Hong,Lee F. Kuyper,Michael L. Jones

Journal of Heterocyclic Chemistry, no. 1 (1997): 145-151

Cited by3Bibtex

Inhibition of uridine phosphorylase. Synthesis and structure-activity relationships of aryl-substituted 1-((2-hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil

G F Orr,D L Musso,J L Kelley,S S Joyner,S T Davis,D P Baccanari

Journal of medicinal chemistry, no. 8 (1997): 1179-1185

Cited by6WOSBibtex

Structures of Candida albicans dihydrofolate reductase: holoenzyme and ternary inhibitor complexes

K D Hardman,Lee F Kuyper,David P Baccanari,M E Fling,Joseph H Chan,Robert L Tansik, D B Stewart,Marc D Whitlow,A J Howard

Acta Crystallographica Section A, (1996)

Bibtex

STRUCTURES OF CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE: HOLOENZYME AND TERNARY INHIBITOR COMPLEXES

Marc Whitlow,Andrew J. Howard,David Stewart,Karl D. Hardman,Lee F. Kuyper,David P. Baccanari,Mary Fling,Joseph H. Chan,Robert L. Tansik

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, no. SUPnan (1996): C208-C209

Bibtex

Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

Soo Peang Khor,Herb Amyx,Stephen T. Davis,Donald Nelson,David P. Baccanari,Thomas Spector

Cancer Chemotherapy and Pharmacology, no. 3 (1996): 233-238

Cited by15WOSBibtex

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Lee F Kuyper,Janice M Garvey,David P Baccanari,John N Champness,David K Stammers,Christopher R Beddell

BIOORGANIC & MEDICINAL CHEMISTRY, no. 4 (1996): 593-602

Cited by27EIWOSBibtex

URACIL DERIVATIVES AS ENZYME INHIBITORS

James L Kelley,David P Baccanari

(1995)

Bibtex

Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines

J H Chan,J S Hong,L F Kuyper,D P Baccanari,S S Joyner,R L Tansik,C M Boytos,S K Rudolph

Journal of medicinal chemistry, no. 18 (1995): 3608-3616

Cited by8WOSBibtex

5-Ethynyluracil (776C85): Protection from 5-fluorouracil-induced neurotoxicity in dogs

Stephen T. Davis,Suzanne S. Joyner,David P. Baccanari,Thomas Spector

BIOCHEMICAL PHARMACOLOGY, no. 2 (1994): 233-236

Cited by17EIWOSBibtex

5-Ethynyluracil (776C85), a modulator of the therapeutic activity of 5-fluorouracil

Tim D Spector,David J T Porter,D J Nelson,David P Baccanari,Stephen T Davis,Merrick R Almond,S P Khor,H Amyx,Shousong Cao,Youcef M Rustum

Drugs of The Future, (1994)

Cited by38Bibtex

Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine

Stephen T. Davis,Suzanne S. Joyner,Pisal Chandrasurin,David P. Baccanari

BIOCHEMICAL PHARMACOLOGY, no. 1 (1993): 173-181

Cited by10EIWOSBibtex

2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. Part 13. Some Alkenyl Derivatives with High in vitro Activity Against Anaerobic Organisms

Barbara Roth,Mary Y. Tidwell,R. Ferone,D. P. Baccanari,Carl W. Sigel, D. Deangelis, L. P. Elwell

ChemInform, no. 2 (1990)

Bibtex

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms

B Roth,M Y Tidwell,R Ferone,D P Baccanari,C W Sigel,D DeAngelis,L P Elwell

Journal of medicinal chemistry, no. 8 (1989): 1949-1958

Cited by4WOSBibtex

Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate

A Rosowsky,V C Solan,R A Forsch,T J Delcamp,D P Baccanari,J H Freisheim

Journal of medicinal chemistry, no. 8 (1987): 1463-1469

Cited by3WOSBibtex

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

B Roth,B S Rauckman,R Ferone,D P Baccanari,J N Champness,R M Hyde

Journal of medicinal chemistry, no. 2 (1987): 348-356

Cited by18WOSBibtex

Kinetics of methotrexate binding to dihydrofolate reductase from Neisseria gonorrhoeae

David P. Baccanari,Robert L. Tansik

BIOCHEMICAL PHARMACOLOGY, no. 13 (1984): 2101-2107

Cited by1EIWOSBibtex

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