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个人简介
I am a Clinical Pharmacologist funded by an MRC Clinician Scientist Fellowship.
My fellowship is investigating the role of microglia in brain disease. Microglia are referred to as the “policemen of the brain” because they activate in response to almost any brain injury, including degenerative disease like Alzheimer’s and Parkinson’s. The way in which microglia respond to these diseases is very important, because this response partly determines how fast the disease progresses. My focus is on identifying drugs to modulate their responses and therefore slow the progression of these diseases.
In addition, I am Head of Clinical Studies at the NIHR Imperial Clinical Research Facility, a unit which helps Imperial College researchers turn their laboratory discoveries into medicines of the future. At the moment, we are focussed almost exclusively on COVID-19, examining both vaccines and potential treatments.
I spend the remaining ~20% of my time in clinical medicine seeing patients on the acute medical take, leading Pharmacology teaching (with Chris John) at Imperial Medical School, and contributing to committees on the use of medicines. This includes chairing the North West London Integrated Formulary Committee which covers GP practices responsible for approximately 2.6 million people, and chairing the Subregional IVIG committee covering the stewardship of this life saving but scarce resource across 6 NHS Trusts.
If you are interested in working on any of these projects, or wanting to start a new one in this field, please do get in touch.
My fellowship is investigating the role of microglia in brain disease. Microglia are referred to as the “policemen of the brain” because they activate in response to almost any brain injury, including degenerative disease like Alzheimer’s and Parkinson’s. The way in which microglia respond to these diseases is very important, because this response partly determines how fast the disease progresses. My focus is on identifying drugs to modulate their responses and therefore slow the progression of these diseases.
In addition, I am Head of Clinical Studies at the NIHR Imperial Clinical Research Facility, a unit which helps Imperial College researchers turn their laboratory discoveries into medicines of the future. At the moment, we are focussed almost exclusively on COVID-19, examining both vaccines and potential treatments.
I spend the remaining ~20% of my time in clinical medicine seeing patients on the acute medical take, leading Pharmacology teaching (with Chris John) at Imperial Medical School, and contributing to committees on the use of medicines. This includes chairing the North West London Integrated Formulary Committee which covers GP practices responsible for approximately 2.6 million people, and chairing the Subregional IVIG committee covering the stewardship of this life saving but scarce resource across 6 NHS Trusts.
If you are interested in working on any of these projects, or wanting to start a new one in this field, please do get in touch.
研究兴趣
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Jasmini Alagaratnam,John P. Thornhill,Zhen Fan,Jaime H. Vera,Jonathan Underwood, Rebecca Hall, Graham Searle,David Owen,Paul Edison,Sarah Fidler,Alan Winston
Journal of NeuroVirologypp.1-11, (2024)
Stergios Tsartsalis, Hannah Sleven,Nurun Fancy, Frank Wessely,Amy M. Smith,Nanet Willumsen, To Ka Dorcas Cheung,Michal J. Rokicki, Vicky Chau, Eseoghene Ifie,Combiz Khozoie,Olaf Ansorge,
Nature Communicationsno. 1 (2024): 1-19
Quentin Amossé,Benjamin B. Tournier, Aurélien M. Badina, Lilou Marchand-Maillet, Laurene Abjean, Sylvain Lengacher,Nurun Fancy,Amy M. Smith, Ying Ying Leung, Vivien Santer,Valentina Garibotto,David R. Owen,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Andreas-Antonios Roussakis,Marta Gennaro,Mark Forrest Gordon,Ralf Reilmann,Beth Borowsky, Gail Rynkowski,Nicholas P. Lao-Kaim, Zoe Papoutsou,Juha-Matti Savola,Michael R. Hayden,David R. Owen,Nicola Kalk,
BRAIN COMMUNICATIONSno. 2 (2023): fcad084-fcad084
European radiologyno. 12 (2023): 9223-9232
Benjamin Cooze,Ildiko Farkas, Yeung Yeung Leung, Kelsey Allen, James Neal,Djordje Gveric,Srivastava Prashant,Richard Nicholas,David Owen,Richard Reynolds,Owain Howell
MULTIPLE SCLEROSIS JOURNAL (2023): 209-210
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Sarah Knowles,Rod Middleton, Benjamin Cooze,Ildiko Farkas, Yeung Yeung Leung,David Owen, James Neal,Richard Reynolds,Owen Pearson,Richard Nicholas,Owen Pickrell,Owain Howell
MULTIPLE SCLEROSIS JOURNAL (2023): 94-95
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Erik Nutma,Nurun Fancy,Maria Weinert,Stergios Tsartsalis,Manuel C Marzin,Robert C J Muirhead, Irene Falk,Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman,Jasper Anink,
Nature communicationsno. 1 (2023): 5247-5247
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