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职业迁徙
个人简介
The major focus of my laboratory is on self/non-self discrimination and immune response in B lymphocytes, with an increasing interest in self/nonself discrimination in the innate immune response. We have extensive expertise in using molecular biology and reverse genetics to simplify or humanize the mouse immune system to ask specific research questions. In addition to our studies on immune tolerance, we have contributed to understanding of vaccinology by assessing the pathways required for adjuvant activity and the role of inhibitory Siglec receptors. A more recent interest is in generating and studying human anti-viral antibody mouse models to speed vaccine research and to explore the barriers limiting the anti-viral response to subdominant epitopes. This work has led to insights into how best to prime B cells to generate a broadly neutralizing immune response to the CD4 binding site of HIV and to the stem region of Influenza virus.
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Meng Yuan,Linghang Peng,Deli Huang,Amanda Gavin, Fangkun Luan, Jenny Tran, Ziqi Feng,Xueyong Zhu, Jeanne Matteson,Ian A. Wilson,David Nemazee
Structure (2024)
Immunityno. 3 (2023): 669-686.e7
Jonathan Hurtado, Claudia Flynn,Jeong Hyun Lee, Eugenia C. Salcedo,Christopher A. Cottrell,Patrick D. Skog,Dennis R. Burton,David Nemazee,William R. Schief,Elise Landais,Devin Sok,Bryan Briney
biorxiv(2023)
bioRxiv : the preprint server for biology (2023)
Shridhar Bale,Lifei Yang, Mehrdad Alirezaei,Richard Wilson,Takayuki Ota, Esmeralda D Doyle,Christopher A Cottrell,Javier Guenaga,Karen Tran,Wenjuan Li,Leonidas Stamatatos,David Nemazee,
Frontiers in immunology (2023): 1180959-1180959
A. J. Gavin,Tanya R. Blane, Terri Thinnes, Emma Gerlt,Ann Marshak‐Rothstein,Deli Huang,David Nemazee
ImmunoHorizonsno. 8 (2023): 577-586
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Meng Yuan,Xueyong Zhu,Wan-Ting He,Panpan Zhou,Chengzi I Kaku,Tazio Capozzola, Connie Y Zhu, Xinye Yu,Hejun Liu,Wenli Yu,Yuanzi Hua,Henry Tien,
Michael K. Okoreeh,Domenick E. Kennedy,Akinola Olumide Emmanuel,Margaret Veselits,Azam Moshin, Robert H. Ladd,Steven Erickson,Kaitlin C. McLean, Brianna Madrigal,David Nemazee,Mark Maienschein-Cline,Malay Mandal,
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