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职业迁徙
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My laboratory studies CD8 and CD4 T cell responses to a variety of viral and bacterial infections to help understand the development of immunological protection from re-infection. We observe and manipulate pathogen specific T cell responses over time by using MHC tetramers, adoptive transfer of transgenic T cells, fluorescence flow cytometry and sorting, and gene microarry analysis. Upon activation in lymphoid tissue, rare pathogen-specific naïve T cells proliferate, acquire effector functions, disseminate throughout the organism, and contribute to the eradication of pathogens. In situations where antigen is successfully eliminated, most effector T cells die by apoptosis. However, a fraction of effector T cells escape death and differentiate into long-lived memory T cells that contribute to protective immunity. We are currently dedicated to elucidating the developmental cues that govern T cell migration to different anatomical locations, commitment to the memory lineage, and the contribution of memory T cell differentiation state and location to protection from re-infection. Memory T cells that reside at common portals of pathogen entry or infection, especially the intestinal mucosa, are of particular interest. By understanding these issues, we hope to contribute to the development of better vaccination strategies, and are currently focused on informing development of a protective HIV vaccine.
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论文共 226 篇作者统计合作学者相似作者
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Journal of Immunologyno. 1 (2023): 228.09-228.09
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Andrew G. Soerens,Marco Künzli,Clare F. Quarnstrom,Milcah C. Scott, Lee Swanson, JJ. Locquiao,Hazem E. Ghoneim,Dietmar Zehn,Benjamin Youngblood,Vaiva Vezys,David Masopust
Journal of Immunologyno. 1_Supplement (2023): 61.26-61.26
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Caitlin C. Zebley,Tian Mi,Andrew Soerens,Shanta Alli, Anoop Vasandan, Christopher Hines, April Mueller,Stephen Baylin,Peter Jones, Harris Goldstein,Charles Mullighan,David Masopust,
Journal of Immunologyno. 1 (2023): 148.07-148.07
Gut Microbesno. 2 (2023): 2266627
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JOURNAL OF IMMUNOLOGYno. 84 (2023): A1069-A1069
JOURNAL OF IMMUNOLOGYno. 1 (2023)
Vineet Joag,Benjamin Bimber,Clare Quarnstrom,Venkata Satish Bollimpelli,Jason M. Schenkel, Mario Bertogliat, Stephen O'Flanagan,Andrew Soerens,Michael Stolley,Eric Hunter,Rama Rao Amara,David Masopust
The Journal of Immunologyno. 1 (2023): 114.15-114.15
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