基本信息
浏览量:0
职业迁徙
个人简介
Research Summary
The goal of David Breslow's current research is understanding the functions of the mammalian primary cilium, a micron-scale structure protruding from the surface of most cells in the human body. Overlooked for many years, the cilium has recently been found to control key aspects of cellular and organismal physiology and to be disrupted in a group of pediatric diseases known as ciliopathies. Using a combination of functional screening, microscopy and biochemistry, the Breslow lab is investigating the basic processes by which cilia are assembled, maintained, and disassembled. Areas of particular interest include understanding how the cilium serves as an essential organizing center for select signaling pathways (e.g. Hedgehog signal transduction) and dissecting the complex interplay between cell cycle progression and regulation of of cilium assembly/disassembly. Together these studies aim to provide fundamental biological insights, to shed light on the pathogenic mechanisms of ciliopathies, and to reveal new strategies for targeting Hedgehog-driven cancers.
Research Interests
Cell Compartmentation; Cell Cycle; Cell Biology; Homeostasis; Signal Transduction; Genomics; Organelle Shape; High-Throughput Screening Assays
The goal of David Breslow's current research is understanding the functions of the mammalian primary cilium, a micron-scale structure protruding from the surface of most cells in the human body. Overlooked for many years, the cilium has recently been found to control key aspects of cellular and organismal physiology and to be disrupted in a group of pediatric diseases known as ciliopathies. Using a combination of functional screening, microscopy and biochemistry, the Breslow lab is investigating the basic processes by which cilia are assembled, maintained, and disassembled. Areas of particular interest include understanding how the cilium serves as an essential organizing center for select signaling pathways (e.g. Hedgehog signal transduction) and dissecting the complex interplay between cell cycle progression and regulation of of cilium assembly/disassembly. Together these studies aim to provide fundamental biological insights, to shed light on the pathogenic mechanisms of ciliopathies, and to reveal new strategies for targeting Hedgehog-driven cancers.
Research Interests
Cell Compartmentation; Cell Cycle; Cell Biology; Homeostasis; Signal Transduction; Genomics; Organelle Shape; High-Throughput Screening Assays
研究兴趣
论文共 21 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Anil Kumar Ganga, Lauren K Sweeney, Armando Rubio Ramos, Cassandra S Bishop,Virginie Hamel,Paul Guichard,David K Breslow
bioRxiv : the preprint server for biology (2024)
Ange-Line Bruel,Anil Kumar Ganga,Lenka Noskova,Irene Valenzuela,Jelena Martinovic,Yannis Duffourd,Marie Zikanova,Filip Majer,Stanislav Kmoch,Marketa Mohler, Jingbo Sun, Lauren K. Sweeney,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn