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His primary focus clinically is therapy of advanced lung cancer. He has published more than 310 peer-reviewed papers, and edited the text Lung Cancer: Prevention, Management and Emerging Therapies published in 2010. His primary area of research interest is personalization of therapy using tools that include phase I and II clinical trials, studies of plasma pharmacokinetics and tumor and normal tissue uptake of chemotherapy agents, resistance mechanisms, resistance modulation, and host single nucleotide polymorphisms and tumor biomarkers that correlate with treatment outcome and prognosis. He also has a major interest in and concern for issues impeding cancer clinical research, with publications that have included (among others) Cancer: the road to Amiens (Journal of Clinical Oncology 27(3):328-33, 1/2009), Equipoise lost: ethics, costs and the regulation of cancer clinical research (Journal of Clinical Oncology 28(17):2925-35, 2010), Fool’s gold, lost treasures and the randomized clinical trial (BMC Cancer 2013 Apr;13(1):193),and Redefining cancer: a new paradigm for better and faster treatment innovation. J Popul Ther Clin Pharmacol 2014 Feb 23; 21(1):e56-e65).
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Journal of clinical oncology : official journal of the American Society of Clinical Oncologyno. 8 (2024): 973-974
Current oncology (Toronto, Ont.)no. 9 (2023): 8310-8327
crossref(2023)
Oncologic Imaging : a Multidisciplinary Approachpp.57-78, (2023)
Elsevier eBookspp.57-78, (2023)
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FRONTIERS IN HEALTH SERVICES (2023): 1015621
CANCER RESEARCHno. 12 (2022)
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Cancer Researchno. 12_Supplement (2022): 6299-6299
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