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个人简介
David Mangelsdorf’s research focuses on two signal transduction pathways with therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism. The first pathway is governed by nuclear hormone receptors, a class of ligand-dependent transcription factors that affect numerous developmental and metabolic processes. The second pathway is mediated by the endocrine fibroblast growth factors FGF19 and FGF21, which control energy metabolism in response to nutrient availability. Mangelsdorf and his team seek to understand the molecular and physiological components of these pathways, using approaches in biochemistry, pharmacology, physiology, and structural biology.
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Cell Metabolismno. 3 (2023): 429-+
Frontiers in oncology (2023): 1025443
Mohammad Abu-Odeh,Yuan Zhang, Shannon M Reilly, Nima Ebadat,Omer Keinan,Joseph M Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer,Lana Mamoun,Xin Zhou,Jin Zhang, Ruth T Yu,
Cell reportsno. 13 (2021): 109331-109331
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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