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Using the developmental genetic model system Caenorhabditis elegans, we are characterizing genes responsible for morphogenesis, a collection of fundamental developmental mechanisms that shape and organize cells into particular forms. C. elegans is used for this study because it is complex enough to share components and mechanisms of more complex multicellular animals, but is simple enough to be described in complete terms. The structure we are using as a model for morphogenesis is the sexually dimorphic tail tip. This simple feature is constructed of only 4 cells that, in males only, fuse very late in juvenile ("larval") development and change their cellular structure and position. This results in a blunt shape (the pointy shape of the hermaphrodite tail results from lack of morphogenetic change). We've finished a complete transmission electron microscopic reconstruction of these cellular events using serial sections, providing a descriptive foundation for further functional studies. We have isolated several mutations that fail at certain steps of male tail tip morphogenesis, and are currently cloning the genes defined by these mutations to understand their molecular functions.
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bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
Karin C Kiontke, R. Antonio Herrera, D. Adam Mason, Yash Patel, Stephanie Vernooy,Alyssa Woronik,David H.A. Fitch
crossref(2024)
Karin Kiontke, R Antonio Herrera, D Adam Mason,Alyssa Woronik, Stephanie Vernooy, Yash Patel,David H A Fitch
bioRxiv : the preprint server for biology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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microPublication biology (2023)
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bioRxiv : the preprint server for biology (2023)
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David H. A. Fitch, Steven A. Frank
The Quarterly Review of Biologyno. 4 (2023): 231-232
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