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个人简介
Dr. Beer has published over 150 peer-reviewed original research articles and has focused on two main research areas currently funded by NIH: the molecular genetics of human lung cancer and the molecular characterization of genes critical to human esophageal adenocarcinoma development. He has pioneered the use of gene and protein expression profiling for the identification of patients with high-risk early stage lung cancers. Ongoing studies include collaborative efforts to examine large cohorts of patients with lung cancer using gene expression profiling, the development of robust technologies for clinical application of potential predictive gene and protein profiles and the analysis of the patient's humoral response to cancer and specific autoantibodies for cancer detection and prognosis. In the esophagus current work involves the identification and characterization of amplified genomic regions in Barrett's esophageal adenocarcinomas utilizing tools such as oligonucleotide and SNP arrays, comparative genome hybridization and gene expression profiling. These studies have revealed a number of potentially critical genes that are involved in the development and progression of this cancer. Dr. Beer's research team has also identified novel amplicons and ongoing research involves the functional characterization of amplified candidate genes and the development of methods to utilize these genes for early detection and targets for therapy.
研究兴趣
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Srimathi Kasturirangan,Derek J. Nancarrow, Ayush Shah,Kiran H. Lagisetty,Theodore S. Lawrence,David G. Beer,Dipankar Ray
Cell Death & Diseaseno. 3 (2024): 1-12
Vasudha Murlidhar,Rishindra M. Reddy,Shamileh Fouladdel,Lili Zhao, Martin K. Ishikawa, Svetlana Grabauskiene,Zhuo Zhang,Jules Lin,Andrew C. Chang,Philip Carrott,William R. Lynch,Mark B. Orringer,
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