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Our group focuses on the intracellular signaling events that control the growth and differentiation of normal and malignant cells. Extracellular stimuli lead to a cascade of events that culminates in the regulation of gene expression. It is the activation or repression of specific genes that then determines cellular function. We study how these signaling events occur normally by examining the activation of kinase cascades, transcriptional networks, and key target genes. Among the mediators we have focused on are STAT transcription factors, which can be modulated by both tyrosine and serine phosphorylation, and thus may serve as a convergence point for multiple signaling pathways. Thus, one of the areas of focus in our group is how STATs, alone and in conjunction with other transcription factors, modulate gene expression throughout the genome.
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论文共 327 篇作者统计合作学者相似作者
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Jennifer I. Brown,Rosanne Persaud, Petar Iliev, Ujjwala Karmacharya,Sanaz Attarha, Henok Sahile, Jonas E. Olsen, Danielle Hanke, Temilolu Idowu,David A. Frank,Adam Frankel,Karla C. Williams,
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 115971-115971
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Clinical Lymphoma Myeloma and Leukemia (2023): S181
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Penn State University Press eBookspp.247-264, (2023)
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Laura E. Stevens,Guillermo Peluffo,Xintao Qiu, Daniel Temko,Anne Fassl,Zheqi Li,Anne Trinh,Marco Seehawer,Bojana Jovanović,Maša Alečković, Callahan M. Wilde,Renee C. Geck,
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JOURNAL OF STUDIES ON ALCOHOL AND DRUGSno. 2 (2023): 222-229
Weiyuan Wang, Melanie Cristina Lopez McDonald,Christine Kim, Mirielle Ma, Zetao (Tommy) Pan, Charlotte Kaufmann,David A. Frank
FRONTIERS IN IMMUNOLOGY (2023): 1265818-1265818
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