Dr. David E. Shapiro is a Principal Research Scientist in the Center for Biostatistics in AIDS Research at the Harvard T. H. Chan School of Public Health and the Director of the NIH-funded Statistical and Data Management Center (SDMC) for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network. Dr. Shapiro has worked as a senior statistician for perinatal and pediatric HIV research studies for over 20 years, as a member of the SDMC for IMPAACT and its predecessor the Pediatric AIDS Clinical Trials Group (PACTG). He served as the SDMC’s Perinatal Section Head from 1995 through 2006, its Associate Director from 2003 through 2010, and has been the SDMC Director since 2010. Dr. Shapiro has taken the lead statistical role in 24 perinatal and pediatric HIV clinical trials, including Phase I, II, and III trials and observational studies in the U.S. and internationally, and has served as a member or chair of the independent data and safety monitoring committee for three clinical trials. He has authored or co-authored over 60 peer-reviewed publications. Dr. Shapiro’s statistical research interests and publications focus on methodology for assessing the accuracy of diagnostic and screening tests.