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Dr. Gutterman's investigative interests focus on regulation of human vascular reactivity both at the fundamental and translational research levels. His work has defined a novel mechanism whereby a switch occurs in the mediator of flow-induced dilation from nitric oxide to shear-released mitochondria-derived hydrogen peroxide in the microcirculation of patients with coronary artery disease. The cellular mechanism of this switch is under active investigation with emerging roles for extranuclear telomerase, short chain ceramides, and autophagy as key modulators of mitochondrial ROS.
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PHYSIOLOGY (2023)
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CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTIONno. 12 (2023)
Kaleigh Kozak,Alexa Derayunan, Rosinda De La Pena,Andreas M. Beyer,David D. Gutterman,Jennifer McIntosh
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