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Throughout his tenure as an administrator at HHMI, Clayton remained active in research, and his laboratory has been based at Janelia Farm since it opened in 2006. A biochemist, he has studied the human mitochondrial genome and has made important discoveries about its genetic content and mechanisms of its replication and expression. This has led to fundamental insights in how defects in mitochondrial genes cause disease. His research group is currently using high-resolution imaging techniques to better understand mitochondrial structure, how the mitochondrial genome is organized with proteins and distributed throughout the cell, and how the mitochondria trade information with other parts of the cell.
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Cold Spring Harbor protocolsno. 10 (2014): pdb.prot080010-pdb.prot080010
Cold Spring Harbor protocolsno. 10 (2014): pdb.prot080002-pdb.prot080002
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