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RESEARCH INTERESTS
My laboratory investigates the microcirculatory movement of fluid and macromolecules. Our interests include the control and regulation of fluid and macromolecular exchange and transport throughout the three microcirculatory compartments: the microvascular compartment, the interstitial compartment, and the lymphatic compartment.
We are investigating both the normal physiological control and pathophysiological alterations of these functions. We have focused most of our recent work on the function of the lymphatic system and are investigating the mechanisms responsible for the generation and regulation of lymph flow.
The lymphatic system is vital to body fluid/protein homeostasis, edema prevention, lymphocyte circulation, immune function and lipid absorption. All of these functions require a regulated lymph flow. We are investigating the influence of physical, neural and humoral factors on the generation of lymph flow with particular emphasis on the mechanisms by which these factors alter the active lymph pump. Mammalian lymphatics possess intrinsic phasic contractions that pump lymph throughout the body and tonic contractions that regulate outflow resistance. The cellular mechanisms regulating the lymphatic contractions are unknown and are the subject of our current studies.
My laboratory investigates the microcirculatory movement of fluid and macromolecules. Our interests include the control and regulation of fluid and macromolecular exchange and transport throughout the three microcirculatory compartments: the microvascular compartment, the interstitial compartment, and the lymphatic compartment.
We are investigating both the normal physiological control and pathophysiological alterations of these functions. We have focused most of our recent work on the function of the lymphatic system and are investigating the mechanisms responsible for the generation and regulation of lymph flow.
The lymphatic system is vital to body fluid/protein homeostasis, edema prevention, lymphocyte circulation, immune function and lipid absorption. All of these functions require a regulated lymph flow. We are investigating the influence of physical, neural and humoral factors on the generation of lymph flow with particular emphasis on the mechanisms by which these factors alter the active lymph pump. Mammalian lymphatics possess intrinsic phasic contractions that pump lymph throughout the body and tonic contractions that regulate outflow resistance. The cellular mechanisms regulating the lymphatic contractions are unknown and are the subject of our current studies.
研究兴趣
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Ahmed F. Pantho, Lorena Amaral,Syeda Afroze,Niraj Vora,Thomas J. Kuehl,David C. Zawieja, Birdie B. LaMarca,Mohammad N. Uddin
HYPERTENSION (2023)
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JOURNAL OF INVESTIGATIVE MEDICINEno. 7 (2023): 209-213
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JOURNAL OF INVESTIGATIVE MEDICINEno. 7 (2023): 52-52
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Waverly B Kundysek,Ahmed Pantho,Syeda H Afroze,Niraj Vora,Thomas J. Kuehl,David C. Zawieja,Mohammad Nasir Uddin
Hypertensionno. Suppl_1 (2023)
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Waverly B. Kundysek, Ahmed Pantho, Syeda Afroze,Niraj Vora,Thomas Kuehl,David C. Zawieja,Mohammad N. Uddin
HYPERTENSION (2023)
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HYPERTENSIONno. Suppl_1 (2023)
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