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The Harrowven group seeks to develop new methodologies and strategies to facilitate the rapid synthesis of high-value organic molecules, especially those with unusual molecular architectures. Interests extend to reagent free transformations using synthetic photochemistry, thermal rearrangements, cascade reactions and daisy-chain processes. Notable recent achievements in the field of natural products total syntheses include the first synthesis of the potent antimicrobial marine natural product chrysophaentin F, and the first synthesis of the macrocyclic bisbibenzyl polymorphatin A with two boat configured aromatic rings in its core structure. These successes build on past achievements that include syntheses of (–)-colombiasin A, (–)-elisapterosin B, riccardin C, pseudopterosin and cavicularin.
Recent highlights in method development include new procedures to efficiently prepare medium-sized rings through ring expansion; a thermally induced C-H activation for the synthesis of nitrogen heterocycles; and a body of research on the thermal and photochemical rearrangement chemistry of cyclobutenones giving access to a host of fused and spirocyclic ring systems. The latter includes a curious example of diradical intermediate where a carbon-centred radical can also act as a base or an electrophile via orbital isomers.
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Marian Powderly,Mélanie Roseau,Gilles Frison,David Harrowven,Julien Legros,Isabelle Chataigner, Rayane Hammami,Laetitia Chausset-Boissarie
Chemical Communicationsno. 72 (2023): 10797-10800
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CHEMISTRYSELECTno. 29 (2023)
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The 3rd International Conference on the Challenges, Opportunities, Innovations and Applications in Electronic Textiles (2022)
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