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个人简介
Over 20 year's experience in the genomics field and have participated in all of the large national projects involving DNA sequencing from the finishing of the human reference genome to the construction of the human haplotype map, 1000 genomes and The Cancer Genome Atlas project. I've worked with Sanger capillary sequence data, and have been instrumental in the development of methods for analyzing sequence data from each of the commercially available instruments (LifeTech, Illumina, Roche 454, PacBio, and Oxford Nanopore). I was the lead author on the analysis of James Watson's genome, the first human genome to be sequenced by a second generation sequencer. The heart of the Human Genome Sequencing Center, flagship of the fleet are 14 Illumina X Ten, which can sequence up to 2,500 human genomes per month. The X Ten is augmented by 8 HiSeq 2000, 2 MiSeq, PacBio Sequel and 2 Oxford Nanopore MinIONs. In March we procured a NovaSeq 6000. The breadth of instrumentation in our Center gives us a bird's eye view of the sequencing landscape. We have sequenced over 5,000 cancer patients in the past 8 years in addition to larger cohorts of normal and disease human populations. More recently I have analyzed in great detail NGS DNA and RNA sequence from dozens of individual cancer patients in a research capacity to demonstrate the capability of NGS in designing treatments for patients.
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论文共 434 篇作者统计合作学者相似作者
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NUCLEIC ACIDS RESEARCHno. 4 (2024): 1688-1701
Patroula Nathanailidou,Jothy Dhakshnamoorthy, Hua Xiao,Martin Zofall,Sahana Holla, Maura O'Neill, Thorkell Andresson,David Wheeler,Shiv I S Grewal
Proceedings of the National Academy of Sciences of the United States of Americano. 6 (2024): e2315596121-e2315596121
GENES CHROMOSOMES & CANCERno. 1 (2024)
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Vincent Gaggioli, Calvin S. Y. Lo,Nazaret Reverón-Gómez,Zuzana Jasencakova, Heura Domenech, Hong Nguyen,Simone Sidoli,Andrey Tvardovskiy, Sidrit Uruci,Johan A. Slotman, Yi Chai,João G. S. C. Souto Gonçalves,
Nature cell biologyno. 7 (2023): 1017-1032
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Lu Wang, Victor Pastor Loyola,Scott Foy,Maria Cardenas,Jamie Maciaszek,Priyadarshini Kumar,Alexander Gout,Gout Mark Wilkinson, Jennifer Neary,Zonggao Shi,David Wheeler,Jeffrey Rubnitz,
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Jude Jessie Bond,Gordon Refshauge,Matthew T. Newell,Benjamin W. B. Holman,David Wheeler, Serey Woodgate,Karthik S. Kamath,Richard C. Hayes
Proteomesno. 27 (2023): 27-27
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