Darren W. Engers - Department of ChemistryInstitute of Chemical Biology, Vanderbilt University

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Papers共 119 篇Author StatisticsCo-AuthorSimilar Experts

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Discovery of Pre-Clinical Candidate VU6008055/AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust in Vivo Efficacy

Julie L Engers,Sean R Bollinger, Alison R Gregro, Rory A Capstick, Paul K Spearing,Madeline F Long,James C Tarr, Katherine J Watson, Sichen Chang,Vincent B Luscombe,Alice L Rodriguez,Hyekyung P Cho,Aidong Qi, Colleen M Niswender,Michael Bubser,Robert W Gould, William Hudson Robb,Nellie Byun, John Gore,Carrie K Jones, Morten S Thomsen,Thomas M Bridges,Olivier Boutaud,P Jeffrey Conn,Darren W Engers,Craig W Lindsley,Kayla J Temple

ACS chemical neuroscienceno. 11 (2025): 2141-2162

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Correction to "discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (Twik-Related K+ Channel 2) Preferring Activator in Vivo Tool Compound"

Kentaro Yashiro,Yuzo Iwaki, Hirohito Urata,Masaya Kokubo, Takahiro Mori, Yoko Sekioka, Koichi Isami, Junya Kato,Joshua Wieting,Kevin M McGowan,Thomas M Bridges,Olivier Boutaud,Darren W Engers,Jerod S Denton,Haruto Kurata,Craig W Lindsley

ACS chemical neuroscience (2025)

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Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound

Motoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, Katsukuni Mitsui, Akihiro Kishi, Elizabeth S Childress,Sean R Bollinger, Trevor C Chopko,Thomas M Bridges, Douglas G Stafford, Zhonping Huang, Mark A Wolf,Darren W Engers,Jerod S Denton, Haruto Kurata,Craig W Lindsley

ACS medicinal chemistry lettersno. 5 (2025): 896-901

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Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: the Discovery of VU6045422

Julie L Engers, Jinming Li,Changho Han,Madeline F Long, Alison R Gregro, Christopher C Presley,Jonathan W Dickerson, Weimin Peng,Hyekyung P Cho,Alice L Rodriguez,Zixiu Xiang,Olivier Boutaud, Colin O'Carroll, P Markus Dey,Ethan S Burstein,Colleen M Niswender,Jerri M Rook,P Jeffrey Conn,Darren W Engers,Craig W Lindsley

ACS chemical neuroscienceno. 8 (2025): 1582-1591

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Total Synthesis and Pharmacological Evaluation of Phochrodines A-C

Jacob L Bouchard, Sichen Chang, Srinivasan Krishnan, Christopher C Presley,Olivier Boutaud,Nathan D Schley,Darren W Engers,Julie L Engers,Craig W Lindsley,Aaron M Bender

Journal of natural productsno. 4 (2025): 996-1003

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Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile

Rory A. Capstick,Sean R. Bollinger,Julie L. Engers,Madeline F. Long,Sichen Chang,Vincent B. Luscombe,Alice L. Rodriguez,Colleen M. Niswender,Thomas M. Bridges,Olivier Boutaud,P. Jeffrey Conn,Darren W. Engers,Craig W. Lindsley,Kayla J. Temple

ACS Medicinal Chemistry Letters（2024）

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The Cannabinoid CB2 Receptor Positive Allosteric Modulator EC21a Exhibits Complicated Pharmacology in Vitro

Aidong Qi, Xueqing Han,Marc Quitalig, Jessica Wu,Plamen P. Christov,KyuOk Jeon,Somnath Jana,Kwangho Kim,Darren W. Engers,Craig W. Lindsley,Alice L. Rodriguez,Colleen M. Niswender

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTIONno. 4 (2024): 151-159

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

Julie L. Engers, Logan A. Baker,Sichen Chang,Vincent B. Luscombe,Alice L. Rodriguez,Colleen M. Niswender,Hyekyung P. Cho,Michael Bubser,Analisa Thompson Gray,Carrie K. Jones,Weimin Peng,Jerri M. Rook,Thomas M. Bridges,Olivier Boutaud,P. Jeffrey Conn,Darren W. Engers,Craig W. Lindsley,Kayla J. Temple

ACS CHEMICAL NEUROSCIENCEno. 20 (2024): 3744-3754

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Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer’s Disease

Jeremy S Coleman,Rory A Capstick, Upendra A Rathnayake, Lauren Parr,Sichen Chang,Analisa D Thompson,Aidong Qi,Colleen M Niswender,Olivier Boutaud, Hyekyung Plumley,Carrie K Jones,Darren Engers,Craig W Lindsley

Alzheimer's &amp Dementiano. S21 (2023)

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