Dapeng Chen - Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc

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KT-253, A Novel MDM2 Degrader and P53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors

Yogesh K Chutake, Michele F Mayo, Nancy Dumont,Jessica Filiatrault, Susanne B Breitkopf,Patricia Cho,Dapeng Chen, Vaishali S Dixit, William R Proctor, Eric W Kuhn, Sarah Bollinger Martinez,Alice A McDonald, Jianfeng Qi,Kan-Nian Hu,Rahul Karnik,Joseph D Growney,Kirti Sharma,Stefanie S Schalm, Ashwin M Gollerkeri,Nello Mainolfi, Juliet A Williams,Matthew M Weiss

Molecular cancer therapeuticsno. 4 (2025): 497-510

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Discovery of the First Clinical Protein Degrader for the Treatment of Autoimmune Indications: Orally Bioavailable and Selective IRAK4 Degrader KT-474

Xiaozhang Zheng,Nan Ji,Veronica Campbell,Anthony Slavin,Xiao Zhu,Dapeng Chen,Haojing Rong, Brad Enerson,Michele Mayo,Kirti Sharma, Chris M. Browne,Christine R. Klaus, Haoran Li, Ginny Massa,Alice A. McDonald,Yatao Shi,Mike Sintchak,Stephanie Skouras,Dirk M. Walther,Karen Yuan, Yi Zhang, Joe Kelleher, Guang Liu, Xinbo Luo,Nello Mainolfi,Matthew M. Weiss

JOURNAL OF MEDICINAL CHEMISTRYno. 20 (2024): 18022-18037

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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma

Matthew M. Weiss,Xiaozhang Zheng,Nan Ji, Chris M. Browne,Veronica Campbell,Dapeng Chen, Brad Enerson, Xue Fei, Xin Huang,Christine R. Klaus, Haoran Li,Michele Mayo,Alice A. McDonald,Atanu Paul,Haojing Rong,Kirti Sharma,Yatao Shi,Anthony Slavin,Dirk M. Walther,Karen Yuan, Yi Zhang,Xiao Zhu, Joe Kelleher,Duncan Walker,Nello Mainolfi

JOURNAL OF MEDICINAL CHEMISTRY (2024)

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Prediction of Pharmacokinetics and Pharmacodynamics in Human for IRAK4 Targeted Protein Degrader

Dapeng Chen,Haojing Rong,Michele Mayo,Alice McDonald,Veronica Campbell,Xiaozhang Zheng,Sagar Agarwal,Matt Weiss,Anthony Slavin

DRUG METABOLISM AND PHARMACOKINETICS (2024)

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P464: PULSE DOSING OF POTENT AND SELECTIVE HETEROBIFUNCTIONAL MDM2 DEGRADER KT-253 DRIVES TUMOR REGRESSION AND DEMONSTRATES DIFFERENTIATED PHARMACOLOGY COMPARED TO P53/MDM2 SMALL MOLECULE INHIBITORS

Stefanie Schalm,Yogesh Chutake,Susanne Breitkopf,Michele Mayo, Nancy Dumont,Dapeng Chen,Vaishali Dixit,Rahul Karnik,Alice Mcdonald,Jessica Filiatrault,William Proctor, Frank Qi,Kan-Nian Hu,Matt Weiss,Ashwin Gollerkeri,Kirti Sharma,Joseph D Growney,Juliet Williams

HemaSphereno. S3 (2023)

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Developing a Mechanistic Understanding of the Nonlinear Pharmacokinetics of Letermovir and Prospective Drug Interaction with Everolimus Using Physiological-Based Pharmacokinetic Modeling

Karsten Menzel,Yuhsin Kuo,Dapeng Chen,Georgy Hartmann,Ying-Hong Wang,Carolyn R. Cho,Jacqueline B. McCrea, Kazuhiko Asari

CTS-CLINICAL AND TRANSLATIONAL SCIENCE（2023）

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IRAK4 Degrader in Hidradenitis Suppurativa and Atopic Dermatitis: a Phase 1 Trial

Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, Phillip La Stella,Afsaneh Alavi,Ashwin Gollerkeri, Jeffrey Davis,Veronica Campbell,Alice McDonald,Sagar Agarwal,Rahul Karnik, Kelvin Shi, Aimee Mishkin, Jennifer Culbertson,Christine Klaus,Bradley Enerson, Virginia Massa, Eric Kuhn,Kirti Sharma,Erin Keaney, Randy Barnes,Dapeng Chen,Xiaozhang Zheng,Haojing Rong, Vijay Sabesan,Chris Ho,Nello Mainolfi,Anthony Slavin,Jared A. Gollob

Nature Medicineno. 12 (2023): 3127-3136

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KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Wildtype P53 Tumors with Superior Potency and Differentiated Biological Activity Compared to Small Molecule Inhibitors (SMI)

Yogesh Chutake,Michele Mayo,Dapeng Chen,Bradley Enerson,Patricia Cho,Jessica Filiatrault, Crystal Brown, Michael Placke, Madison Adams,Rahul Karnik, James Shaw,Yatao Shi,Dirk Walther,Alice McDonald, Frank Qi,Phillip Liu,Joseph D. Growney,Kirti Sharma,Duncan Walker,Stefanie Schalm,Juliet Williams,Matthew Weiss

Cancer Researchno. 12_Supplement (2022): 3934-3934

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