基本信息
浏览量:166
职业迁徙
个人简介
My interests are in the field of in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) and the development of new methods of imaging metabolism within the body. Current projects include 13C MRS of hyperpolarized substrates for the assessment of glycolysis, oxidative phosphorylation, and other key metabolic pathways, optimized mapping of 1H metabolite distributions throughout the body, and quantifying neurotransmitter levels and cycling rates in the brain. In our laboratory, we have focussed on a novel array of both acquisition and analysis techniques for use in preclinical and clinical studies. These developments, which include improved spectroscopic imaging and shimming methods, multinuclear NMR studies, application of estimation theory for optimal data quantification, and the synthesis of new hyperpolarizeable 13C probes, address the inherent difficulties of low concentrations of the desired components, overlapping resonances, and magnetic field inhomogeneities caused by imperfect magnets and magnetic susceptibility variations with the body. Primary applications of this work include cancer diagnosis, treatment monitoring, and prediction of response to therapy, assessment of cardiac function, improved understanding and treatment of metabolic diseases (e.g. diabetes, liver failure) and neurologic disorders including Alzheimer's disease, schizophrenia, and epilepsy.
研究兴趣
论文共 264 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NMR IN BIOMEDICINEno. 3 (2024)
Magnetic resonance in medicineno. 1 (2023): 39-50
NMR in biomedicineno. 3 (2023): e5073-e5073
Keith P. Van Haren,Kristen Cunanan,Avni Awani,Meng Gu, Dalia Pena,Lindsay C. Chromik,Michal Povazan,Nicole C. Rossi, Jordan Goodman,Vandana Sundaram, Jennifer Winterbottom,Gerald Raymond,
Neurology Geneticsno. 2 (2023): e200061-e200061
Keith P Van Haren,Kristen Cunanan,Avni Awani,Meng Gu, Dalia Peña,Lindsay C Chromik,Michal Považan,Nicole C Rossi,Jordan Goodman,Vandana Sundaram, Jennifer Winterbottom,Gerald V Raymond,
Biological Psychiatryno. 9 (2023): S83-S83
引用0浏览0引用
0
0
Keith Van Haren,Kristen Cunanan,Avni Awani,Meng Gu, Dalia Peña,Lindsay C. Chromik,Michal Považan,Nicole C. Rossi, Jennifer Winterbottom,Jordan Goodman,Vandana Sundaram,Gerald V Raymond,
medrxiv(2022)
K. Van Haren,K. Cunanan, A. Awani, M. Gu, D. Pena,L. C. Chromik, M. Povazan, N. C. Rossi, J. Winterbottom, J. Goodman, V. Sundaram, G. Raymond,
NEUROPSYCHOPHARMACOLOGY (2022): 302-303
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn